an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: AGC group; Delta subfamily; EC 18.104.22.168; Kinase, protein; Nuclear receptor co-regulator; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Molecular Function: calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; kinase binding; protein binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; apoptosis; defense response to bacterium; histone phosphorylation; induction of apoptosis by oxidative stress; negative regulation of actin filament polymerization; negative regulation of filopodium formation; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein binding; neutrophil activation; neutrophil degranulation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phospholipase C activation; platelet activation; positive regulation of endodeoxyribonuclease activity; positive regulation of protein amino acid dephosphorylation; positive regulation of protein import into nucleus; positive regulation of superoxide release; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of mRNA stability; regulation of receptor activity; signal transduction; stimulatory C-type lectin receptor signaling pathway