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Protein Page:
PKCD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKCD an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Tumor suppressor; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Nuclear receptor co-regulator; EC 2.7.11.13; AGC group; PKC family; Delta subfamily
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; nucleoplasm; nucleus; plasma membrane
Molecular Function: calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; kinase binding; protein binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; apoptosis; cell structure disassembly during apoptosis; defense response to bacterium; histone phosphorylation; induction of apoptosis by oxidative stress; negative regulation of actin filament polymerization; negative regulation of filopodium formation; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein binding; neutrophil activation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phospholipase C activation; platelet activation; positive regulation of endodeoxyribonuclease activity; positive regulation of protein amino acid dephosphorylation; positive regulation of protein import into nucleus; positive regulation of superoxide release; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of mRNA stability; regulation of receptor activity; signal transduction; stimulatory C-type lectin receptor signaling pathway
Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii
Reference #:  Q05655 (UniProtKB)
Alt. Names/Synonyms: KPCD; MAY1; MGC49908; nPKC-delta; PKCD; PRKCD; Protein kinase C delta type; protein kinase C delta VIII; protein kinase C, delta
Gene Symbols: PRKCD
Molecular weight: 77,505 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKCD

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
apoptosis, altered: Y52‑p, Y64‑p, Y187‑p, Y313‑p, T507‑p
apoptosis, induced: Y64‑p, Y187‑p, Y334‑p
cell motility, induced: Y313‑p
transcription, inhibited: Y313‑p
activity, inhibited: Y52‑p, Y64‑p, Y187‑p
enzymatic activity, altered: Y313‑p, S359‑p
enzymatic activity, induced: T141‑p, T295‑p, T507‑p
intracellular localization: S299‑p
molecular association, regulation: Y313‑p, Y334‑p
phosphorylation: Y64‑p, Y187‑p, Y313‑p, T507‑p
protein conformation: Y313‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S37 VKMKEALSTERGKtL
0 1 T38 KMKEALSTERGKtLV
0 5 T43‑p LSTERGKtLVQKKPt
0 1 K47 RGKtLVQKKPtMyPE
0 4 T50‑p tLVQKKPtMyPEWKS
4 0 Y52‑p VQKKPtMyPEWKSTF
7 28 Y64‑p STFDAHIyEGRVIQI
1 8 S130‑p EDVDCKQsMRSEDEA
2 8 T141‑p EDEAKFPtMNRRGAI
9 0 Y155‑p IKQAKIHyIKNHEFI
0 1 T164 KNHEFIATFFGQPTF
0 2 K184‑ub DFVWGLNkQGyKCRQ
6 0 Y187‑p WGLNkQGyKCRQCNA
0 1 T211 IIGRCTGTAANSRDt
0 1 A213 GRCTGTAANSRDtIF
0 1 S215 CTGTAANSRDtIFQk
1 6 T218‑p TAANSRDtIFQkERF
0 3 K222‑ub SRDtIFQkERFNIDM
0 2 H236 MPHRFKVHNYMSPTF
0 1 K271‑ub CGMNVHHkCREKVAN
3 4 T295‑p AEALNQVtQRAsRRs
0 1 T295 AEALNQVTQRAsRRs
1 36 S299‑p NQVtQRAsRRsDsAs
0 1 R301 VtQRAsRRsDsAssE
2 70 S302‑p tQRAsRRsDsAssEP
2 380 S304‑p RAsRRsDsAssEPVG
0 79 S306‑p sRRsDsAssEPVGIy
0 53 S307‑p RRsDsAssEPVGIyQ
0 4 P309 sDsAssEPVGIyQGF
34 1735 Y313‑p ssEPVGIyQGFEKkT
0 1 K319‑ub IyQGFEKkTGVAGED
0 1 - gap
0 5 S331‑p GEDMQDNsGtyGkIW
0 17 T333‑p DMQDNsGtyGkIWEG
13 543 Y334‑p MQDNsGtyGkIWEGs
0 1 K336‑ub DNsGtyGkIWEGssK
0 1 S341‑p yGkIWEGssKCNINN
0 1 S342‑p GkIWEGssKCNINNF
0 1 I350 KCNINNFIFHKVLGK
2 2 S359‑p HKVLGKGsFGkVLLG
0 1 K362‑ub LGKGsFGkVLLGELk
0 5 K369‑ub kVLLGELkGRGEyFA
2 520 Y374‑p ELkGRGEyFAIKALK
0 1 Y448‑p DKGRFELyRAtFyAA
0 1 T451‑p RFELyRAtFyAAEIM
0 1 Y453‑p ELyRAtFyAAEIMCG
0 1 Y471‑p LHSKGIIyRDLKLDN
0 2 R472 HSKGIIyRDLKLDNV
0 4 K496‑ub IADFGMCkENIFGEs
1 15 S503‑p kENIFGEsRAstFCG
0 55 S506‑p IFGEsRAstFCGtPD
41 127 T507‑p FGEsRAstFCGtPDy
0 5 T511‑p RAstFCGtPDyIAPE
3 3 Y514‑p tFCGtPDyIAPEILQ
3 0 Y525‑p EILQGLKyTFSVDWW
5 0 Y567‑p IRVDTPHyPRWITKE
0 1 T594‑p PTKRLGVtGNIKIHP
0 1 T594 PTKRLGVTGNIKIHP
0 1 T605‑p KIHPFFKtINWtLLE
0 2 T609‑p FFKtINWtLLEkRRL
0 1 K613‑ub INWtLLEkRRLEPPF
1 27 Y630‑p KVKSPRDysNFDQEF
0 1 S631‑p VKSPRDysNFDQEFL
0 3 K641‑ub DQEFLNEkARLsysD
21 119 S645‑p LNEkARLsysDKNLI
0 24 Y646‑p NEkARLsysDKNLID
0 54 S647‑p EkARLsysDKNLIDs
0 13 S654‑p sDKNLIDsMDQsAFA
0 6 S658‑p LIDsMDQsAFAGFsF
9 123 S664‑p QsAFAGFsFVNPKFE
2055 : Phospho-PKCdelta (Tyr311) Antibody
14787 : Phospho-PKC delta (Ser359) (D2X1P) Rabbit mAb
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9374 : Phospho-PKCdelta (Thr505) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
38938 : Phospho-PKC (pan) (gamma Thr514) (D6Y3D) Rabbit mAb
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  PKCD iso2  
S37 VKMKEALSTERGKTL
T38 KMKEALSTERGKTLV
T43 LSTERGKTLVQKKPT
K47 RGKTLVQKKPTMYPE
T50 TLVQKKPTMYPEWKS
Y52 VQKKPTMYPEWKSTF
Y64 STFDAHIYEGRVIQI
S130 EDVDCKQSMRSEDEA
T141 EDEAKFPTMNRRGAI
Y155 IKQAKIHYIKNHEFI
T164 KNHEFIATFFGQPTF
K184 DFVWGLNKQGYKCRQ
Y187 WGLNKQGYKCRQCNA
T211 IIGRCTGTAANSRDT
A213 GRCTGTAANSRDTIF
S215 CTGTAANSRDTIFQK
T218 TAANSRDTIFQKERF
K222 SRDTIFQKERFNIDM
H236 MPHRFKVHNYMSPTF
K271 CGMNVHHKCREKVAN
T295 AEALNQVTQRASRRS
T295 AEALNQVTQRASRRS
S299 NQVTQRASRRSDSAS
R301 VTQRASRRSDSASSE
S302 TQRASRRSDSASSEP
S304 RASRRSDSASSEPVG
S306 SRRSDSASSEPVGIY
S307 RRSDSASSEPVGIYQ
P309 SDSASSEPVGIYQGF
Y313 SSEPVGIYQGFEKKT
K319 IYQGFEKKTGVAGED
- gap
S362 CQVRQDNSGTYGKIW
T364 VRQDNSGTYGKIWEG
Y365 RQDNSGTYGKIWEGS
K367 DNSGTYGKIWEGSSK
S372 YGKIWEGSSKCNINN
S373 GKIWEGSSKCNINNF
I381 KCNINNFIFHKVLGK
S390 HKVLGKGSFGKVLLG
K393 LGKGSFGKVLLGELK
K400 KVLLGELKGRGEYFA
Y405 ELKGRGEYFAIKALK
Y479 DKGRFELYRATFYAA
T482 RFELYRATFYAAEIM
Y484 ELYRATFYAAEIMCG
Y502 LHSKGIIYRDLKLDN
R503 HSKGIIYRDLKLDNV
K527 IADFGMCKENIFGES
S534 KENIFGESRASTFCG
S537 IFGESRASTFCGTPD
T538 FGESRASTFCGTPDY
T542 RASTFCGTPDYIAPE
Y545 TFCGTPDYIAPEILQ
Y556 EILQGLKYTFSVDWW
Y598 IRVDTPHYPRWITKE
T625 PTKRLGVTGNIKIHP
T625 PTKRLGVTGNIKIHP
T636 KIHPFFKTINWTLLE
T640 FFKTINWTLLEKRRL
K644 INWTLLEKRRLEPPF
Y661 KVKSPRDYSNFDQEF
S662 VKSPRDYSNFDQEFL
K672 DQEFLNEKARLSYSD
S676 LNEKARLSYSDKNLI
Y677 NEKARLSYSDKNLID
S678 EKARLSYSDKNLIDS
S685 SDKNLIDSMDQSAFA
S689 LIDSMDQSAFAGFSF
S695 QSAFAGFSFVNPKFE
  mouse

► Hide Isoforms
 
S37 VKMKEALSTERGKtL
T38 KMKEALSTERGKtLV
T43‑p LSTERGKtLVQkKPT
K47‑ac RGKtLVQkKPTMyPE
T50 tLVQkKPTMyPEWKT
Y52‑p VQkKPTMyPEWKTTF
Y64‑p TTFDAHIyEGRVIQI
S130‑p EDGDCKQsMRSEEEA
T141‑p EEEAKFPtMNRRGAI
Y155‑p IKQAKIHyIKNHEFI
T164 KNHEFIATFFGQPTF
K184‑ub EFVWGLNkQGyKCRQ
Y187‑p WGLNkQGyKCRQCNA
T211 IIGRCTGTATNSRDT
T213 GRCTGTATNSRDTIF
S215 CTGTATNSRDTIFQk
T218 TATNSRDTIFQkERF
K222‑ub SRDTIFQkERFNIDM
Y236‑p MPHRFKVyNYMSPTF
K271 CGMNVHHKCREKVAN
T295 AEALNQVTQRSSRkL
T295 AEALNQVTQRSSRkL
S299 NQVTQRSSRkLDTTE
K301‑ub VTQRSSRkLDTTEsV
- gap
- gap
T304 RSSRkLDTTEsVGIy
T305 SSRkLDTTEsVGIyQ
S307‑p RkLDTTEsVGIyQGF
Y311‑p TTEsVGIyQGFEKKP
K317 IyQGFEKKPEVSGsD
S323‑p KKPEVSGsDILDNNG
N329 GsDILDNNGTyGKIW
T331 DILDNNGTyGKIWEG
Y332‑p ILDNNGTyGKIWEGS
K334 DNNGTyGKIWEGSTR
S339 yGKIWEGSTRCTLEN
T340 GKIWEGSTRCTLENF
T348 RCTLENFTFQKVLGK
S357 QKVLGKGSFGKVLLA
K360 LGKGSFGKVLLAELK
K367 KVLLAELKGKDKyFA
Y372‑p ELKGKDKyFAIKCLK
Y446 DKGRFELYRATFYAA
T449 RFELYRATFYAAEII
Y451 ELYRATFYAAEIICG
Y469 LHSKGIIYrDLKLDN
R470‑m1 HSKGIIYrDLKLDNV
K494 IADFGMCKENIFGEG
G501 KENIFGEGRAstFCG
S504‑p IFGEGRAstFCGtPD
T505‑p FGEGRAstFCGtPDY
T509‑p RAstFCGtPDYIAPE
Y512 tFCGtPDYIAPEILQ
Y523 EILQGLKYSFSVDWW
Y565‑p IRVDTPHyPRWITKE
T592 PDKRLGVTGNIRIHP
T592 PDKRLGVTGNIRIHP
T603 RIHPFFKTINWSLLE
S607 FFKTINWSLLEKRKV
K611 INWSLLEKRKVEPPF
Y628 KVKSPSDYSNFDPEF
S629 VKSPSDYSNFDPEFL
K639 DPEFLNEKPQLsFsD
S643‑p LNEKPQLsFsDKNLI
F644 NEKPQLsFsDKNLID
S645‑p EKPQLsFsDKNLIDs
S652‑p sDKNLIDsMDQEAFH
E656 LIDsMDQEAFHGFsF
S662‑p QEAFHGFsFVNPKFE
2055 : Phospho-PKCdelta (Tyr311) Antibody
14787 : Phospho-PKC delta (Ser359) (D2X1P) Rabbit mAb
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9374 : Phospho-PKCdelta (Thr505) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
38938 : Phospho-PKC (pan) (gamma Thr514) (D6Y3D) Rabbit mAb
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
  PKCD iso2  
S37 VKMKEALSTERGKTL
T38 KMKEALSTERGKTLV
T43 LSTERGKTLVQKKPT
K47 RGKTLVQKKPTMYPE
T50 TLVQKKPTMYPEWKT
Y52 VQKKPTMYPEWKTTF
Y64 TTFDAHIYEGRVIQI
S130 EDGDCKQSMRSEEEA
T141 EEEAKFPTMNRRGAI
Y155 IKQAKIHYIKNHEFI
T164 KNHEFIATFFGQPTF
K184 EFVWGLNKQGYKCRQ
Y187 WGLNKQGYKCRQCNA
T211 IIGRCTGTATNSRDT
T213 GRCTGTATNSRDTIF
S215 CTGTATNSRDTIFQK
T218 TATNSRDTIFQKERF
K222 SRDTIFQKERFNIDM
Y236 MPHRFKVYNYMSPTF
K271 CGMNVHHKCREKVAN
T295 AEALNQVTQRSSRKL
T295 AEALNQVTQRSSRKL
S299 NQVTQRSSRKLDTTE
K301 VTQRSSRKLDTTESV
- gap
- gap
T304 RSSRKLDTTESVGIY
T305 SSRKLDTTESVGIYQ
S307 RKLDTTESVGIYQGF
Y311 TTESVGIYQGFEKKP
K317 IYQGFEKKPEVSGSD
S323 KKPEVSGSDILGEAG
N355 SSETCDNNGTYGKIW
T357 ETCDNNGTYGKIWEG
Y358 TCDNNGTYGKIWEGS
K360 DNNGTYGKIWEGSTR
S365 YGKIWEGSTRCTLEN
T366 GKIWEGSTRCTLENF
T374 RCTLENFTFQKVLGK
S383 QKVLGKGSFGKVLLA
K386 LGKGSFGKVLLAELK
K393 KVLLAELKGKDKYFA
Y398 ELKGKDKYFAIKCLK
Y472 DKGRFELYRATFYAA
T475 RFELYRATFYAAEII
Y477 ELYRATFYAAEIICG
Y495 LHSKGIIYRDLKLDN
R496 HSKGIIYRDLKLDNV
K520 IADFGMCKENIFGEG
G527 KENIFGEGRASTFCG
S530 IFGEGRASTFCGTPD
T531 FGEGRASTFCGTPDY
T535 RASTFCGTPDYIAPE
Y538 TFCGTPDYIAPEILQ
Y549 EILQGLKYSFSVDWW
Y591 IRVDTPHYPRWITKE
T618 PDKRLGVTGNIRIHP
T618 PDKRLGVTGNIRIHP
T629 RIHPFFKTINWSLLE
S633 FFKTINWSLLEKRKV
K637 INWSLLEKRKVEPPF
Y654 KVKSPSDYSNFDPEF
S655 VKSPSDYSNFDPEFL
K665 DPEFLNEKPQLSFSD
S669 LNEKPQLSFSDKNLI
F670 NEKPQLSFSDKNLID
S671 EKPQLSFSDKNLIDS
S678 SDKNLIDSMDQEAFH
E682 LIDSMDQEAFHGFSF
S688 QEAFHGFSFVNPKFE
  rat

 
T37‑p VKMKEALttDRGKTL
T38‑p KMKEALttDRGKTLV
T43 LttDRGKTLVQKKPt
K47 RGKTLVQKKPtMYPE
T50‑p TLVQKKPtMYPEWKS
Y52 VQKKPtMYPEWKSTF
Y64‑p STFDAHIyEGRVIQI
S130‑p EDGDCKQsMRSEEEA
T141‑p EEEAMFPtMNRRGAI
Y155‑p IKQAKIHyIKNHEFI
T164‑p KNHEFIAtFFGQPTF
K184 EFVWGLNKQGYKCRQ
Y187 WGLNKQGYKCRQCNA
T211‑p IIGRCTGtAtNsRDt
T213‑p GRCTGtAtNsRDtIF
S215‑p CTGtAtNsRDtIFQK
T218‑p tAtNsRDtIFQKERF
K222 sRDtIFQKERFNIDM
Y236 MPHRFKVYNYMSPTF
K271 CGMNVHHKCREKVAN
T295‑p AEALNQVtQKAsRKP
T295‑gl AEALNQVtQKAsRKP
S299‑p NQVtQKAsRKPETPE
K301 VtQKAsRKPETPETV
- gap
- gap
T304 KAsRKPETPETVGIy
P305 AsRKPETPETVGIyQ
T307 RKPETPETVGIyQGF
Y311‑p TPETVGIyQGFEKKT
K317 IyQGFEKKTAVSGND
- gap
N329 GNDIPDNNGTyGKIW
T331 DIPDNNGTyGKIWEG
Y332‑p IPDNNGTyGKIWEGS
K334 DNNGTyGKIWEGSNR
S339 yGKIWEGSNRCRLEN
N340 GKIWEGSNRCRLENF
T348‑gl RCRLENFtFQKVLGK
S357‑p QKVLGKGsFGKVLLA
K360 LGKGsFGKVLLAELK
K367 KVLLAELKGKERyFA
Y372‑p ELKGKERyFAIKYLK
Y446 DKGRFELYRATFYAA
T449 RFELYRATFYAAEII
Y451 ELYRATFYAAEIICG
Y469 LHGKGIIYRDLKLDN
R470 HGKGIIYRDLKLDNV
K494 IADFGMCKENIFGEN
N501 KENIFGENRAstFCG
S504‑p IFGENRAstFCGTPD
T505‑p FGENRAstFCGTPDy
T509 RAstFCGTPDyIAPE
Y512‑p tFCGTPDyIAPEILQ
Y523‑p EILQGLKySFSVDWW
Y565‑p IRVDTPHyPRWITKE
T592 PAKRLGVTGNIRLHP
T592‑gl PAKRLGVtGNIRLHP
T603 RLHPFFKTINWNLLE
N607 FFKTINWNLLEKRKV
K611 INWNLLEKRKVEPPF
Y628‑p KVKSPSDySNFDPEF
S629 VKSPSDySNFDPEFL
K639 DPEFLNEKPQLsFsD
S643‑p LNEKPQLsFsDKNLI
F644 NEKPQLsFsDKNLID
S645‑p EKPQLsFsDKNLIDS
S652 sDKNLIDSMDQtAFK
T656‑p LIDSMDQtAFKGFsF
S662‑p QtAFKGFsFVNPKYE
2055 : Phospho-PKCdelta (Tyr311) Antibody
14787 : Phospho-PKC delta (Ser359) (D2X1P) Rabbit mAb
2060 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb
5016 : Phospho-PKC (pan) (zeta Thr410) (190D10) Rabbit mAb (Biotinylated)
9374 : Phospho-PKCdelta (Thr505) Antibody
9379 : Phospho-PKC (pan) (gamma Thr514) Antibody
38938 : Phospho-PKC (pan) (gamma Thr514) (D6Y3D) Rabbit mAb
9376 : Phospho-PKCdelta/theta (Ser643/676) Antibody
9371 : Phospho-PKC (pan) (betaII Ser660) Antibody
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