an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, AGC; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; Nuclear receptor co-regulator; AGC group; PKC family; Delta subfamily
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; intercellular junction; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: ATP binding; calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; kinase binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: apoptosis; B cell proliferation; blood coagulation; cell cycle; cell structure disassembly during apoptosis; cytokine and chemokine mediated signaling pathway; defense response to bacterium; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; histone phosphorylation; immunoglobulin mediated immune response; induction of apoptosis by oxidative stress; innate immune response; interleukin-10 production; interleukin-12 production; negative regulation of actin filament polymerization; negative regulation of filopodium formation; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein binding; nerve growth factor receptor signaling pathway; neutrophil activation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; phospholipase C activation; platelet activation; positive regulation of endodeoxyribonuclease activity; positive regulation of protein amino acid dephosphorylation; positive regulation of protein import into nucleus; positive regulation of superoxide release; programmed cell death; protein amino acid phosphorylation; protein stabilization; regulation of actin cytoskeleton organization and biogenesis; regulation of mRNA stability; regulation of receptor activity; signal transduction; stimulatory C-type lectin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.