Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
MYO5A (mouse)

MYO5A Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Cellular Component: actin filament; actomyosin; actomyosin, myosin complex part; axon; cell soma; cytoplasm; cytosol; dendrite; early endosome; endoplasmic reticulum; filopodium tip; Golgi apparatus; intermediate filament; late endosome; lysosome; melanosome; membrane; myosin complex; neuron projection; peroxisome; photoreceptor outer segment; recycling endosome; ribonucleoprotein complex; ruffle; secretory granule; synaptic vesicle; vesicle
Molecular Function: actin binding; ATP binding; ATP-dependent protein binding; calcium ion binding; calcium-dependent protein binding; calmodulin binding; microfilament motor activity; motor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein kinase binding; Rab GTPase binding; SNARE binding; syntaxin-1 binding
Biological Process: actin filament-based movement; anagen; cellular response to insulin stimulus; ER localization; exocytosis; insulin secretion; locomotion during locomotory behavior; long-chain fatty acid biosynthetic process; melanin biosynthetic process; melanin metabolic process; melanocyte differentiation; melanosome localization; melanosome transport; myelination; neuromuscular process controlling balance; odontogenesis; pigmentation; pigmentation during development; post-Golgi vesicle-mediated transport; regulation of exocytosis; regulation of inositol-1,4,5-triphosphate receptor activity; secretory granule localization; synapse organization and biogenesis; synaptic transmission; vesicle transport along actin filament; vesicle-mediated transport; visual perception
Reference #:  Q99104 (UniProtKB)
Alt. Names/Synonyms: 9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; Dilute; dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; flail; flailer; flr; MVa; Myo5; Myo5a; myosin VA; Myosin-Va; MyoVA; Sev-1
Gene Symbols: Myo5a
Molecular weight: 215,538 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene