Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation. May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP. Interacts with RIPL2, the interaction is required for its role in dendrite formation. Detected in melanocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: actin binding; ATP binding; ATP-dependent protein binding; calcium ion binding; calcium-dependent protein binding; calmodulin binding; microfilament motor activity; motor activity; nucleotide binding; protein binding; protein dimerization activity; protein heterodimerization activity; Rab GTPase binding; SNARE binding; syntaxin-1 binding
Biological Process: actin filament-based movement; anagen; cellular response to insulin stimulus; ER localization; exocytosis; insulin secretion; locomotion during locomotory behavior; long-chain fatty acid biosynthetic process; melanin biosynthetic process; melanin metabolic process; melanocyte differentiation; melanosome localization; melanosome transport; myelination; neuromuscular process controlling balance; odontogenesis; pigmentation; pigmentation during development; post-Golgi vesicle-mediated transport; protein transport; regulation of exocytosis; regulation of inositol-1,4,5-triphosphate receptor activity; secretory granule localization; synapse organization and biogenesis; synaptic transmission; transport; vesicle transport along actin filament; vesicle-mediated transport; visual perception
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.