TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the TFIIF alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Transcription initiation complex; Kinase, protein; ATYPICAL group; GTF2F1 family
Molecular Function: catalytic activity; DNA binding; phosphatase activator activity; protein binding; transcription coactivator activity; transcription factor binding
Biological Process: gene expression; mRNA capping; nuclear mRNA splicing, via spliceosome; positive regulation of catalytic activity; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; response to virus; RNA elongation from RNA polymerase II promoter; RNA splicing; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.