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Protein Page:
BIRC4BP (human)

Overview
BIRC4BP Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytosol
Reference #:  Q6GPH4 (UniProtKB)
Alt. Names/Synonyms: BIRC4 binding protein; BIRC4-binding protein; BIRC4BP; HSXIAPAF1; XAF1; XIAP associated factor 1; XIAP-associated factor 1; XIAPAF1
Gene Symbols: XAF1
Molecular weight: 34,626 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BIRC4BP

Protein Structure Not Found.
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