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Protein Page:
IRS1 (human)

Overview
IRS1 an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q36
Cellular Component: caveola; cytoplasm; cytosol; intracellular membrane-bound organelle; nucleus; plasma membrane
Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; insulin-like growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; protein kinase C binding; Ras guanyl-nucleotide exchange factor activity; SH2 domain binding; signal transducer activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: cellular response to insulin stimulus; glucose homeostasis; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; regulation of phosphoinositide 3-kinase cascade; response to insulin stimulus; response to peptide hormone stimulus; signal transduction
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  P35568 (UniProtKB)
Alt. Names/Synonyms: HIRS-1; Insulin receptor substrate 1; IRS-1; IRS1
Gene Symbols: IRS1
Molecular weight: 131,591 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IRS1

Protein Structure Not Found.
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