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Protein Page:
NT-3 (human)

Overview
NT-3 Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region
Molecular Function: chemoattractant activity; growth factor activity; nerve growth factor binding; neurotrophin p75 receptor binding; protein binding; receptor binding
Biological Process: activation of MAPK activity; activation of protein kinase B; axon guidance; brain development; cell-cell signaling; enteric nervous system development; epidermis development; glial cell fate determination; induction of positive chemotaxis; mechanoreceptor differentiation; myelination; negative regulation of neuron apoptosis; negative regulation of peptidyl-tyrosine phosphorylation; nerve development; nervous system development; neurite morphogenesis; neuromuscular synaptic transmission; peripheral nervous system development; positive chemotaxis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of glial cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of neuron differentiation; regulation of synaptic transmission; signal transduction; smooth muscle cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P20783 (UniProtKB)
Alt. Names/Synonyms: HDNF; MGC129711; Nerve growth factor 2; neurotrophin 3; Neurotrophin-3; NGF-2; NGF2; NT-3; NT3; NTF3
Gene Symbols: NTF3
Molecular weight: 29,355 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Select Structure to View Below

NT-3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S2 ______MSILFYVIF
0 1 Y99‑p LLRQQRRyNSPRVLL
0 1 Y123‑p PLYLMEDyVGSPVVA
0 1 S156 YSVCDSESLWVTDKS
  NT-3 iso2  
S15‑p LQVNKVMsILFYVIF
Y112 LLRQQRRYNSPRVLL
Y136 PLYLMEDYVGSPVVA
S169 YSVCDSESLWVTDKS
  mouse

 
S2 ______MSILFYVIF
Y99 LLRQQRRYNSPRVLL
Y123 PLYLMEDYVGNPVVA
S157‑p YSVCDSEsLWVTDKS
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