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Protein Page:
JMJD2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JMJD2A Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family. Note: This description may include information from UniProtKB.
Protein type: Demethylase; Oxidoreductase; EC 1.14.11.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: centric heterochromatin; cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process: cardiac muscle hypertrophy; DNA repair; double-strand break repair; establishment and/or maintenance of chromatin architecture; histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; viral reproduction
Reference #:  O75164 (UniProtKB)
Alt. Names/Synonyms: JHDM3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; KDM4A; KIAA0677; lysine (K)-specific demethylase 4A; Lysine-specific demethylase 4A
Gene Symbols: KDM4A
Molecular weight: 120,662 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JMJD2A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T7‑p _MASESEtLNPsARI
0 1 S11‑p ESEtLNPsARIMtFY
0 1 T16‑p NPsARIMtFYPTMEE
0 1 K105‑ub RKIANSDkYCTPRYS
0 21 T155‑p WNIGRLRtILDLVEK
0 1 K224‑ub KRLERLAkGFFPGSA
0 1 K241‑ac CEAFLRHkMTLISPL
0 1 K251‑ac LISPLMLkKYGIPFD
0 1 S307 GKQAVLCSCRKDMVK
0 1 P360 FLKESELPPRAGNEE
0 1 T452‑p RQVEDGLtFPDYSDS
0 3 S502‑p VGGRLVFsGSkKKSS
0 1 K505‑ac RLVFsGSkKKSSSSL
0 1 S514‑p KSSSSLGsGssRDsI
0 1 S516‑p SSSLGsGssRDsISs
0 1 S517‑p SSLGsGssRDsISsD
0 1 S520‑p GsGssRDsISsDSET
0 6 S523‑p ssRDsISsDSETSEP
0 1 Y547‑p GVLTVHSyAKGDGRV
0 1 S570 KKGSAARSFSERELA
0 1 S616‑p LVLQECVsDDETSEQ
0 1 T732 PYLEEDGTSILVSCK
0 1 S733 YLEEDGTSILVSCKK
0 1 K820‑ub RSPVDVSkIPLPRFK
0 1 S1019‑p KRVKSRLsVASDMRF
0 1 Y1053‑p NSRYREDyIEPALyR
0 1 Y1059‑p DyIEPALyRAIME__
  mouse

 
T7 _MASESETLNPSARI
S11 ESETLNPSARIMTFY
T16 NPSARIMTFYPTMEE
K105 RKIANSDKYCTPRYS
T155 WNIGRLKTILDLVEK
K224 KRLERLAKGFFPGSA
K241 CEAFLRHKMTLISPL
K251 LISPLMLKKYGIPFD
S307‑p GKQAVLCsCRKDMVK
T361‑p LKDSGGLtPRAGSEE
P452 RQVEDSLPFPDYSDP
S502‑p VGGRLVFsGSKKKSS
K505 RLVFsGSKKKSSSSL
S514 KSSSSLGSTSSQDSV
S516 SSSLGSTSSQDSVSS
S517 SSLGSTSSQDSVSSD
S520 GSTSSQDSVSSDSET
S523 SSQDSVSSDSETAES
Y547 GVLTVHSYARGDGKA
S570‑p KKRSAPRsISEQELA
S616 LVLQECGSDDETSEQ
T732‑p PYLEEDGtsMLVSCK
S733‑p YLEEDGtsMLVSCKK
K820 RSPVDVSKIPLPRFK
S1019 KRVKSRLSVASDMRF
Y1053 NSRYREDYIEPALYR
Y1059 DYIEPALYRAIME__
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