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Protein Page:
SHANK2 iso4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHANK2 iso4 Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. Defects in SHANK2 are a cause of susceptibility to autism type 17 (AUTS17). Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. Belongs to the SHANK family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: apical plasma membrane; brush border membrane; cell soma; dendritic spine; growth cone; ionotropic glutamate receptor complex; neurofilament; neuron projection; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function: ionotropic glutamate receptor binding; protein binding
Biological Process: adult behavior; learning; social behavior; synaptogenesis
Disease: Autism, Susceptibility To, 17
Reference #:  Q9UPX8-4 (UniProtKB)
Alt. Names/Synonyms: cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CORTBP1; CTTNBP1; GKAP/SAPAP interacting protein; KIAA1022; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHAN2; SHANK; SHANK2; SPANK-3
Gene Symbols: SHANK2
Molecular weight: 134,931 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Select Structure to View Below

SHANK2 iso4

Protein Structure Not Found.


cBioPortal  |  Wikipedia  |  Scansite  |  Pfam  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 2 S41‑p APRVLLRsNsDNNLN
0 10 S43‑p RVLLRsNsDNNLNAS
0 2 S65‑p STATSHRsLsPQLLQ
0 5 S67‑p ATSHRsLsPQLLQQM
0 1 S76‑p QLLQQMPsKPEGAAK
0 1 T84‑p KPEGAAKtIGsyVPG
0 1 S87‑p GAAKtIGsyVPGPRs
0 10 Y88‑p AAKtIGsyVPGPRsR
0 2 S94‑p syVPGPRsRSPSLNR
1 0 S98 GPRsRSPSLNRLGGA
0 1 S120‑p QPLWHVGsPFALGAN
0 36 Y144‑p PGPKRKLySAVPGRL
0 3 S231 FRHYTVGSYDSFDTS
0 1 Y232 RHYTVGSYDSFDTSS
0 4 S234 YTVGSYDSFDTSSDC
0 1 - gap
0 1 - gap
0 1 T339‑p HLVLKVVtVtRNLDP
0 1 T341‑p VLKVVtVtRNLDPDD
0 1 T349‑p RNLDPDDtARKKAPP
0 2 T363‑p PPPKRAPtTALtLRS
0 2 T367‑p RAPtTALtLRSKsMT
0 2 S370 tTALtLRSKsMTSEL
0 8 S372‑p ALtLRSKsMTSELEE
0 1 S375 LRSKsMTSELEELVD
0 1 S400 PEEIVPASKPSRAAE
0 19 Y437‑p GSDMNSVyERQGIAV
0 9 S452‑p MTPTVPGsPKAPFLG
0 1 S470‑p GTMRRQKsIDSRIFL
0 1 S478‑p IDSRIFLsGITEEER
0 6 T481 RIFLsGITEEERQFL
0 1 T481 RIFLsGITEEERQFL
0 1 S514 DIPPPPQSVPPSPPP
0 45 Y538‑p KSPTPRVyGTIKPAF
0 4 K542 PRVyGTIKPAFNQNs
0 1 S549‑p KPAFNQNsAAKVSPA
0 1 K552 FNQNsAAKVSPATRs
0 1 S559‑p KVSPATRsDtVAtMM
0 1 T561‑p SPATRsDtVAtMMRE
0 1 T564‑p TRsDtVAtMMREKGM
0 2 Y580‑p FRRELDRysLDSEDL
0 21 S581‑p RRELDRysLDSEDLy
0 1 S584 LDRysLDSEDLySRN
0 57 Y588‑p sLDSEDLySRNAGPQ
0 229 Y610‑p GQMPENPysEVGKIA
0 16 S611‑p QMPENPysEVGKIAS
0 1 K619 EVGKIASKAVyVPAK
0 9 Y622‑p KIASKAVyVPAKPAR
0 4 S643‑p KQSNVEDsPEKTCSI
0 1 T662‑p IIVKEPStSssGKSS
0 4 S664‑p VKEPStSssGKSSQG
0 3 S665‑p KEPStSssGKSSQGS
0 5 S720‑p RLEARRNsPAFLstD
0 8 S725‑p RNsPAFLstDLGDED
0 3 T726‑p NsPAFLstDLGDEDV
0 1 S813‑p SPAVPSAsSGTAGPG
0 26 Y822‑p GTAGPGNyVHPLtGR
0 1 T827‑p GNyVHPLtGRLLDPS
0 1 S835‑p GRLLDPSsPLALALS
0 26 Y869‑p ADLNKPLyIDTKMRP
0 3 S877‑p IDTKMRPsLDAGFPT
0 1 T886 DAGFPTVTRQNtRGP
0 3 T890‑p PTVTRQNtRGPLRRQ
0 46 T899‑p GPLRRQEtENKyETD
0 9 Y903‑p RQEtENKyETDLGRD
0 3 T905 EtENKyETDLGRDRK
0 1 T939‑p AGLLMVHtVDAtKLD
0 1 T943‑p MVHtVDAtKLDNALQ
0 1 T976 VPEGVSETEGALQIS
0 2 S1001‑p RTIVAVGsMEEAVIL
0 1 S1051‑p IPDDRAAsVPALSDL
0 1 S1064‑p DLVKQKKsDTPQsPs
0 7 S1069‑p KKsDTPQsPsLNSSQ
0 2 S1071‑p sDTPQsPsLNSSQPT
0 1 S1080‑p NSSQPTNsADSKKPA
0 7 S1234‑p GDVTEIKsPILSGPK
0 2 S1269‑p KPGEGLDsPMGAKSA
0 3 S1282‑p SASLAPRsPEIMSTI
0 2 S1287 PRsPEIMSTISGTRS
0 2 T1288 RsPEIMSTISGTRST
0 1 T1288 RsPEIMSTISGTRST
0 1 S1290 PEIMSTISGTRSTTV
0 1 T1292 IMSTISGTRSTTVTF
0 15 S1330‑p SGTRRAPsPVVsPTE
0 14 S1334‑p RAPsPVVsPTEMNKE
0 4 T1336 PsPVVsPTEMNKETL
0 2 S1382‑p GLNPAGRsRsPsPSI
0 2 S1384‑p NPAGRsRsPsPSILQ
0 1 S1386‑p AGRsRsPsPSILQQP
0 1 R1462 GHRMNIERALKQLLD
  SHANK2 iso3  
Y19 MAQSFSDYsVGSESD
S20‑p AQSFSDYsVGSESDS
S28‑p VGSESDSsKEETIYD
T79‑p IRFNPDAtVWVAKQR
Y101‑p SLKDVLNyGLFQPAS
S149‑p KRVYKQAsLDEKQLA
T202‑p ETGETPLtLAAQLDD
S420 APRVLLRSNSDNNLN
S422 RVLLRSNSDNNLNAS
S444 STATSHRSLSPQLLQ
S446 ATSHRSLSPQLLQQM
S455 QLLQQMPSKPEGAAK
T463 KPEGAAKTIGSYVPG
S466 GAAKTIGSYVPGPRS
Y467 AAKTIGSYVPGPRSR
S473 SYVPGPRSRSPSLNR
S477 GPRSRSPSLNRLGGA
S499 QPLWHVGSPFALGAN
Y523 PGPKRKLYSAVPGRL
S610 FRHYTVGSYDSFDTS
Y611 RHYTVGSYDSFDTSS
S613 YTVGSYDSFDTSSDC
- gap
- gap
T718 HLVLKVVTVTRNLDP
T720 VLKVVTVTRNLDPDD
T728 RNLDPDDTARKKAPP
T742 PPPKRAPTTALTLRS
T746 RAPTTALTLRSKSMT
S749 TTALTLRSKSMTSEL
S751 ALTLRSKSMTSELEE
S754 LRSKSMTSELEELVD
S779 PEEIVPASKPSRAAE
Y816 GSDMNSVYERQGIAV
S831 MTPTVPGSPKAPFLG
S849 GTMRRQKSIDSRIFL
S857 IDSRIFLSGITEEER
T860 RIFLSGITEEERQFL
T860 RIFLSGITEEERQFL
S893 DIPPPPQSVPPSPPP
Y917 KSPTPRVYGTIKPAF
K921 PRVYGTIKPAFNQNS
S928 KPAFNQNSAAKVSPA
K931 FNQNSAAKVSPATRS
S938 KVSPATRSDTVATMM
T940 SPATRSDTVATMMRE
T943 TRSDTVATMMREKGM
Y959 FRRELDRYSLDSEDL
S960 RRELDRYSLDSEDLY
S963 LDRYSLDSEDLYSRN
Y967 SLDSEDLYSRNAGPQ
Y989 GQMPENPYSEVGKIA
S990 QMPENPYSEVGKIAS
K998 EVGKIASKAVYVPAK
Y1001 KIASKAVYVPAKPAR
S1022 KQSNVEDSPEKTCSI
T1041 IIVKEPSTSSSGKSS
S1043 VKEPSTSSSGKSSQG
S1044 KEPSTSSSGKSSQGS
S1099 RLEARRNSPAFLSTD
S1104 RNSPAFLSTDLGDED
T1105 NSPAFLSTDLGDEDV
S1192 SPAVPSASSGTAGPG
Y1201 GTAGPGNYVHPLTGR
T1206 GNYVHPLTGRLLDPS
S1214 GRLLDPSSPLALALS
Y1248 ADLNKPLYIDTKMRP
S1256 IDTKMRPSLDAGFPT
T1265 DAGFPTVTRQNTRGP
T1269 PTVTRQNTRGPLRRQ
T1278 GPLRRQETENKYETD
Y1282 RQETENKYETDLGRD
T1284 ETENKYETDLGRDRK
T1318 AGLLMVHTVDATKLD
T1322 MVHTVDATKLDNALQ
T1355 VPEGVSETEGALQIS
S1380 RTIVAVGSMEEAVIL
S1430 IPDDRAASVPALSDL
S1443 DLVKQKKSDTPQSPS
S1448 KKSDTPQSPSLNSSQ
S1450 SDTPQSPSLNSSQPT
S1459 NSSQPTNSADSKKPA
S1613 GDVTEIKSPILSGPK
S1648 KPGEGLDSPMGAKSA
S1661 SASLAPRSPEIMSTI
S1666 PRSPEIMSTISGTRS
T1667 RSPEIMSTISGTRST
T1667 RSPEIMSTISGTRST
S1669 PEIMSTISGTRSTTV
T1671 IMSTISGTRSTTVTF
S1709 SGTRRAPSPVVSPTE
S1713 RAPSPVVSPTEMNKE
T1715 PSPVVSPTEMNKETL
S1761 GLNPAGRSRSPSPSI
S1763 NPAGRSRSPSPSILQ
S1765 AGRSRSPSPSILQQP
R1841 GHRMNIERALKQLLD
  SHANK2 iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T16 GAAAVMMTGYNNGRC
Y29 RCPRNSLYSDCIIEE
T130 HLVLKVVTVTRNLDP
T132 VLKVVTVTRNLDPDD
T140 RNLDPDDTARKKAPP
T154 PPPKRAPTTALTLRS
T158 RAPTTALTLRSKSMT
S161 TTALTLRSKSMTSEL
S163 ALTLRSKSMTSELEE
S166 LRSKSMTSELEELVD
S184 PEEIVPASKPSRAAE
Y221 GSDMNSVYERQGIAV
S236 MTPTVPGSPKAPFLG
S254 GTMRRQKSIDSRIFL
S262 IDSRIFLSGITEEER
T265 RIFLSGITEEERQFL
T265 RIFLSGITEEERQFL
S298 DIPPPPQSVPPSPPP
Y322 KSPTPRVYGTIKPAF
K326 PRVYGTIKPAFNQNS
S333 KPAFNQNSAAKVSPA
K336 FNQNSAAKVSPATRS
S343 KVSPATRSDTVATMM
T345 SPATRSDTVATMMRE
T348 TRSDTVATMMREKGM
Y364 FRRELDRYSLDSEDL
S365 RRELDRYSLDSEDLy
S368 LDRYSLDSEDLySRN
Y372‑p SLDSEDLySRNAGPQ
Y394‑p GQMPENPySEVGKIA
S395 QMPENPySEVGKIAS
K403 EVGKIASKAVYVPAK
Y406 KIASKAVYVPAKPAR
S427 KQSNVEDSPEKTCSI
T446 IIVKEPSTSSSGKSS
S448 VKEPSTSSSGKSSQG
S449 KEPSTSSSGKSSQGS
S504 RLEARRNSPAFLSTD
S509 RNSPAFLSTDLGDED
T510 NSPAFLSTDLGDEDV
S597 SPAVPSASSGTAGPG
Y606 GTAGPGNYVHPLTGR
T611 GNYVHPLTGRLLDPS
S619 GRLLDPSSPLALALS
Y653 ADLNKPLYIDTKMRP
S661 IDTKMRPSLDAGFPT
T670 DAGFPTVTRQNTRGP
T674 PTVTRQNTRGPLRRQ
T683‑p GPLRRQEtENKYETD
Y687 RQEtENKYETDLGRD
T689 EtENKYETDLGRDRK
T723 AGLLMVHTVDATKLD
T727 MVHTVDATKLDNALQ
T760 VPEGVSETEGALQIS
S785 RTIVAVGSMEEAVIL
S835 IPDDRAASVPALSDL
S848 DLVKQKKSDTPQsPS
S853‑p KKSDTPQsPSLNSSQ
S855 SDTPQsPSLNSSQPT
S864 NSSQPTNSADSKKPA
S1018 GDVTEIKSPILSGPK
S1053‑p KPGEGLDsPMGAKSA
S1066 SASLAPRSPEIMSTI
S1071 PRSPEIMSTISGTRS
T1072 RSPEIMSTISGTRST
T1072 RSPEIMSTISGTRST
S1074 PEIMSTISGTRSTTV
T1076 IMSTISGTRSTTVTF
S1114 SGTRRAPSPVVSPTE
S1118 RAPSPVVSPTEMNKE
T1120 PSPVVSPTEMNKETL
S1166 GLNPAGRSRSPSPSI
S1168 NPAGRSRSPSPSILQ
S1170 AGRSRSPSPSILQQP
R1246 GHRMNIERALKQLLD
  SHANK2 iso7  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T16 GAAAVMMTGYNNGRC
Y29 RCPRNSLYSDCIIEE
T130 HLVLKVVTVTRNLDP
T132 VLKVVTVTRNLDPDD
T140 RNLDPDDTARKKAPP
T154 PPPKRAPTTALTLRS
T158 RAPTTALTLRSKsMT
S161 TTALTLRSKsMTsEL
S163‑p ALTLRSKsMTsELEE
S166‑p LRSKsMTsELEELDK
S181 PEEIVPASKPSRAAE
Y218 GSDMNSVYERQGIAV
S233 MTPTVPGSPKAPFLG
S251 GTMRRQKSIGKKCGT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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- gap
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- gap
- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S41 APRVLLRSNsDNNLN
S43‑p RVLLRSNsDNNLNAG
S65 SAATSHRSLsPQLLQ
S67‑p ATSHRSLsPQLLQQT
S76 QLLQQTPSKPDGATK
S84 KPDGATKSLGSYTPG
S87 GATKSLGSYTPGPRS
Y88 ATKSLGSYTPGPRSR
S94 SYTPGPRSRSPSLNR
S98 GPRSRSPSLNRLGGT
S120 QPHWHVGSPFTPGAN
Y144‑p PGPRRKLySAVPGRL
S231‑p FRHYTVGsyDsFDAA
Y232‑p RHYTVGsyDsFDAAS
S234‑p YTVGsyDsFDAASDC
- gap
- gap
T339 HLILKVVTVTRNLDP
T341 ILKVVTVTRNLDPDD
T349 RNLDPDDTARKKAPP
T363‑p PPPKRAPtTALtLRs
T367‑p RAPtTALtLRsKsMT
S370‑p tTALtLRsKsMTAEL
S372‑p ALtLRsKsMTAELEE
A375 LRsKsMTAELEELGL
S404‑gl PEEIVPAsKPSRTAE
Y441 ASDVNSVYERQGIAV
S456‑p MTPTVPGsPKGPFLG
S474 GTMRRQKSIDSRIFL
S482 IDSRIFLSGItEEER
T485‑p RIFLSGItEEERQFL
T485‑gl RIFLSGItEEERQFL
S518‑p DIPPPPQsVPPSPPP
Y542‑p RSPTPRVyGTIKPAF
K546 PRVyGTIKPAFNQNP
P553 KPAFNQNPVVAKVPP
K557 NQNPVVAKVPPATRS
S564 KVPPATRSDTVATMM
T566 PPATRSDTVATMMRE
T569 TRSDTVATMMREKGM
F585 YRRELDRFsLDsEDV
S586‑p RRELDRFsLDsEDVy
S589‑p LDRFsLDsEDVySRS
Y593‑p sLDsEDVySRSPAPQ
Y615‑p GQMPENPysEVGKIA
S616‑p QMPENPysEVGKIAS
K624 EVGKIASKAVYVPAK
Y627 KIASKAVYVPAKPAR
S648‑p KQSNVEDsPEKTCSI
T667 IIVKEPSTSSSGKSS
S669 VKEPSTSSSGKSSQG
S670 KEPSTSSSGKSSQGS
S724‑p RLEARRNsPAFLstD
S729‑p RNsPAFLstDLGDED
T730‑p NsPAFLstDLGDEDV
S817 GPAAPLKSSSPAGPE
Y826 SPAGPENYVHPLTGR
T831 ENYVHPLTGRLLDPS
S839‑p GRLLDPSsPLALALS
Y873 ADLNKPLYIDTKMRP
S881‑p IDTKMRPsVESGFPP
T890‑gl ESGFPPVtRQNtRGP
T894‑p PPVtRQNtRGPLRRQ
T903‑p GPLRRQEtENKYETD
Y907 RQEtENKYETDLGKD
T909 EtENKYETDLGKDRR
T943 AGLLMVHTVDVPMAG
P947 MVHTVDVPMAGPPLE
T980‑gl VPEGVPKtEGALQIS
S1005‑p RTIVAAGsVEEAVIL
S1055 IPDDRAASVPALADL
N1068 DLVKQKKNDTSQPPT
P1073 KKNDTSQPPTLNSSQ
T1075 NDTSQPPTLNSSQPA
S1084 NSSQPANSTDSKKPA
S1238‑p GDVPEVKsPILSGPK
L1273 KPGEGLELPVGAKSA
S1286 SANLAPRSPEVMstV
S1291‑gl PRSPEVMstVsGtRS
T1292‑gl RSPEVMstVsGtRST
T1292‑p RSPEVMstVsGtRST
S1294‑gl PEVMstVsGtRSTTV
T1296‑gl VMstVsGtRSTTVTF
S1334‑p SGPRRAPsPVVsPtE
S1338‑p RAPsPVVsPtELSKE
T1340‑p PsPVVsPtELSKEIL
S1388 GLNPAGRSRSPSPSI
S1390 NPAGRSRSPSPSILQ
S1392 AGRSRSPSPSILQQP
R1468‑m1 GHRMNIErALKQLLD
  SHANK2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
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S41 APRVLLRSNSDNNLN
S43 RVLLRSNSDNNLNAG
S65 SAATSHRSLSPQLLQ
S67 ATSHRSLSPQLLQQT
S76 QLLQQTPSKPDGATK
S84 KPDGATKSLGSYTPG
S87 GATKSLGSYTPGPRS
Y88 ATKSLGSYTPGPRSR
S94 SYTPGPRSRSPSLNR
S98 GPRSRSPSLNRLGGT
S120 QPHWHVGSPFTPGAN
Y144 PGPRRKLYSAVPGRL
S231 FRHYTVGSYDSFDAA
Y232 RHYTVGSYDSFDAAS
S234 YTVGSYDSFDAASDC
- gap
- gap
T339 HLILKVVTVTRNLDP
T341 ILKVVTVTRNLDPDD
T349 RNLDPDDTARKKAPP
T363 PPPKRAPTTALTLRs
T367 RAPTTALTLRsKsMT
S370‑p TTALTLRsKsMTAEL
S372‑p ALTLRsKsMTAELEE
A375 LRsKsMTAELEELVD
S400 PEEIVPASKPSRTAE
Y437 ASDVNSVYERQGIAV
S452 MTPTVPGSPKGPFLG
S470 GTMRRQKSIDSRIFL
S478 IDSRIFLSGITEEER
T481 RIFLSGITEEERQFL
T481 RIFLSGITEEERQFL
S514 DIPPPPQSVPPSPPP
Y538 RSPTPRVYGTIKPAF
K542 PRVYGTIKPAFNQNP
P549 KPAFNQNPVVAKVPP
K553 NQNPVVAKVPPATRS
S560 KVPPATRSDTVATMM
T562 PPATRSDTVATMMRE
T565 TRSDTVATMMREKGM
F581 YRRELDRFSLDSEDV
S582 RRELDRFSLDSEDVY
S585 LDRFSLDSEDVYSRS
Y589 SLDSEDVYSRSPAPQ
Y611 GQMPENPYSEVGKIA
S612 QMPENPYSEVGKIAS
K620 EVGKIASKAVYVPAK
Y623 KIASKAVYVPAKPAR
S644 KQSNVEDSPEKTCSI
T663 IIVKEPSTSSSGKSS
S665 VKEPSTSSSGKSSQG
S666 KEPSTSSSGKSSQGS
S720 RLEARRNSPAFLSTD
S725 RNSPAFLSTDLGDED
T726 NSPAFLSTDLGDEDV
S813 GPAAPLKSSSPAGPE
Y822 SPAGPENYVHPLTGR
T827 ENYVHPLTGRLLDPS
S835 GRLLDPSSPLALALS
Y869 ADLNKPLYIDTKMRP
S877 IDTKMRPSVESGFPP
T886 ESGFPPVTRQNTRGP
T890 PPVTRQNTRGPLRRQ
T899‑p GPLRRQEtENKYETD
Y903 RQEtENKYETDLGKD
T905 EtENKYETDLGKDRR
T939 AGLLMVHTVDVPMAG
P943 MVHTVDVPMAGPPLE
T976 VPEGVPKTEGALQIS
S1001 RTIVAAGSVEEAVIL
S1051 IPDDRAASVPALADL
N1064 DLVKQKKNDTSQPPT
P1069 KKNDTSQPPTLNSSQ
T1071 NDTSQPPTLNSSQPA
S1080 NSSQPANSTDSKKPA
S1234 GDVPEVKSPILSGPK
L1269 KPGEGLELPVGAKSA
S1282 SANLAPRSPEVMSTV
S1287 PRSPEVMSTVSGTRS
T1288 RSPEVMSTVSGTRST
T1288 RSPEVMSTVSGTRST
S1290 PEVMSTVSGTRSTTV
T1292 VMSTVSGTRSTTVTF
S1330 SGPRRAPSPVVSPTE
S1334 RAPSPVVSPTELSKE
T1336 PSPVVSPTELSKEIL
S1384 GLNPAGRSRSPSPSI
S1386 NPAGRSRSPSPSILQ
S1388 AGRSRSPSPSILQQP
R1464 GHRMNIERALKQLLD
  SHANK2 iso3  
Y19‑p MAQSFSDySVGSESD
S20 AQSFSDySVGSESDS
S28 VGSESDSSKEETIYD
T79 IRFNPDATVWVAKQR
Y101 GLKDVLNYGLFQPAS
N149 KRVYKQSNLDEKQLA
T202 ETGETPLTLAAQLDD
S420 APRVLLRSNSDNNLN
S422 RVLLRSNSDNNLNAG
S444 SAATSHRSLSPQLLQ
S446 ATSHRSLSPQLLQQT
S455 QLLQQTPSKPDGATK
S463 KPDGATKSLGSYTPG
S466 GATKSLGSYTPGPRS
Y467 ATKSLGSYTPGPRSR
S473 SYTPGPRSRSPSLNR
S477 GPRSRSPSLNRLGGT
S499 QPHWHVGSPFTPGAN
Y523 PGPRRKLYSAVPGRL
S610 FRHYTVGSYDSFDAA
Y611 RHYTVGSYDSFDAAS
S613 YTVGSYDSFDAASDC
- gap
- gap
T718 HLILKVVTVTRNLDP
T720 ILKVVTVTRNLDPDD
T728 RNLDPDDTARKKAPP
T742 PPPKRAPTTALTLRS
T746 RAPTTALTLRSKSMT
S749 TTALTLRSKSMTAEL
S751 ALTLRSKSMTAELEE
A754 LRSKSMTAELEELDK
S769 PEEIVPASKPSRTAE
Y806 ASDVNSVYERQGIAV
S821 MTPTVPGSPKGPFLG
S839 GTMRRQKSIDSRIFL
S847 IDSRIFLSGITEEER
T850 RIFLSGITEEERQFL
T850 RIFLSGITEEERQFL
S883 DIPPPPQSVPPSPPP
Y907 RSPTPRVYGTIKPAF
K911 PRVYGTIKPAFNQNP
P918 KPAFNQNPVVAKVPP
K922 NQNPVVAKVPPATRS
S929 KVPPATRSDTVATMM
T931 PPATRSDTVATMMRE
T934 TRSDTVATMMREKGM
F950 YRRELDRFSLDSEDV
S951 RRELDRFSLDSEDVY
S954 LDRFSLDSEDVYSRS
Y958 SLDSEDVYSRSPAPQ
Y980 GQMPENPYSEVGKIA
S981 QMPENPYSEVGKIAS
K989 EVGKIASKAVYVPAK
Y992 KIASKAVYVPAKPAR
S1013 KQSNVEDSPEKTCSI
T1032 IIVKEPSTSSSGKSS
S1034 VKEPSTSSSGKSSQG
S1035 KEPSTSSSGKSSQGS
S1089 RLEARRNSPAFLSTD
S1094 RNSPAFLSTDLGDED
T1095 NSPAFLSTDLGDEDV
S1182 GPAAPLKSSSPAGPE
Y1191 SPAGPENYVHPLTGR
T1196 ENYVHPLTGRLLDPS
S1204 GRLLDPSSPLALALS
Y1238 ADLNKPLYIDTKMRP
S1246 IDTKMRPSVESGFPP
T1255 ESGFPPVTRQNTRGP
T1259 PPVTRQNTRGPLRRQ
T1268 GPLRRQETENKYETD
Y1272 RQETENKYETDLGKD
T1274 ETENKYETDLGKDRR
T1308 AGLLMVHTVDVPMAG
P1312 MVHTVDVPMAGPPLE
T1345 VPEGVPKTEGALQIS
S1370 RTIVAAGSVEEAVIL
S1420 IPDDRAASVPALADL
N1433 DLVKQKKNDTSQPPT
P1438 KKNDTSQPPTLNSSQ
T1440 NDTSQPPTLNSSQPA
S1449 NSSQPANSTDSKKPA
S1603 GDVPEVKSPILSGPK
L1638 KPGEGLELPVGAKSA
S1651 SANLAPRSPEVMSTV
S1656 PRSPEVMSTVSGTRS
T1657 RSPEVMSTVSGTRST
T1657 RSPEVMSTVSGTRST
S1659 PEVMSTVSGTRSTTV
T1661 VMSTVSGTRSTTVTF
S1699 SGPRRAPSPVVSPTE
S1703 RAPSPVVSPTELSKE
T1705 PSPVVSPTELSKEIL
S1753 GLNPAGRSRSPSPSI
S1755 NPAGRSRSPSPSILQ
S1757 AGRSRSPSPSILQQP
R1833 GHRMNIERALKQLLD
  SHANK2 iso5  
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T15‑p GAATVMMtGYNNGRY
Y28 RYPRNSLYSDCIIED
T129 HLILKVVTVTRNLDP
T131 ILKVVTVTRNLDPDD
T139 RNLDPDDTARKKAPP
T153 PPPKRAPTTALTLRs
T157 RAPTTALTLRsKsMT
S160‑p TTALTLRsKsMTAEL
S162‑p ALTLRsKsMTAELEE
A165 LRsKsMTAELEELVD
S190 PEEIVPASKPSRTAE
Y227 ASDVNSVYERQGIAV
S242 MTPTVPGSPKGPFLG
S260 GTMRRQKSIDSRIFL
S268 IDSRIFLSGITEEER
T271 RIFLSGITEEERQFL
T271 RIFLSGITEEERQFL
S304 DIPPPPQSVPPSPPP
Y328 RSPTPRVYGTIKPAF
K332 PRVYGTIKPAFNQNP
P339 KPAFNQNPVVAKVPP
K343 NQNPVVAKVPPATRS
S350 KVPPATRSDTVATMM
T352 PPATRSDTVATMMRE
T355 TRSDTVATMMREKGM
F371 YRRELDRFSLDSEDV
S372 RRELDRFSLDSEDVY
S375 LDRFSLDSEDVYSRS
Y379 SLDSEDVYSRSPAPQ
Y401 GQMPENPYSEVGKIA
S402 QMPENPYSEVGKIAS
K410 EVGKIASKAVYVPAK
Y413 KIASKAVYVPAKPAR
S434 KQSNVEDSPEKTCSI
T453 IIVKEPSTSSSGKSS
S455 VKEPSTSSSGKSSQG
S456 KEPSTSSSGKSSQGS
S510 RLEARRNSPAFLSTD
S515 RNSPAFLSTDLGDED
T516 NSPAFLSTDLGDEDV
S603 GPAAPLKSSSPAGPE
Y612 SPAGPENYVHPLTGR
T617 ENYVHPLTGRLLDPS
S625 GRLLDPSSPLALALS
Y659 ADLNKPLYIDTKMRP
S667 IDTKMRPSVESGFPP
T676 ESGFPPVTRQNTRGP
T680 PPVTRQNTRGPLRRQ
T689 GPLRRQETENKYETD
Y693 RQETENKYETDLGKD
T695 ETENKYETDLGKDRR
T729 AGLLMVHTVDVPMAG
P733 MVHTVDVPMAGPPLE
T766 VPEGVPKTEGALQIS
S791 RTIVAAGSVEEAVIL
S841 IPDDRAASVPALADL
N854 DLVKQKKNDTPQPPT
P859 KKNDTPQPPTLNSSQ
T861 NDTPQPPTLNSSQPA
S870 NSSQPANSTDSKKPA
S1024 GDVPEVKSPILSGPK
L1059 KPGEGLELPVGAKSA
S1072 SANLAPRSPEVMSTV
S1077 PRSPEVMSTVSGTRS
T1078 RSPEVMSTVSGTRST
T1078 RSPEVMSTVSGTRST
S1080 PEVMSTVSGTRSTTV
T1082 VMSTVSGTRSTTVTF
S1120 SGPRRAPSPVVSPTE
S1124 RAPSPVVSPTELSKE
T1126 PSPVVSPTELSKEIL
S1174 GLNPAGRSRSPSPSI
S1176 NPAGRSRSPSPSILQ
S1178 AGRSRSPSPSILQQP
R1254 GHRMNIERALKQLLD
  rat

► Hide Isoforms
 
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S41 APRVLLRSNSDNNLN
S43 RVLLRSNSDNNLNAG
S65 SAATSHRSLSPQLLQ
S67 ATSHRSLSPQLLQQT
S76 QLLQQTPSKPDGATK
S84 KPDGATKSLGSyAPG
S87 GATKSLGSyAPGPRS
Y88‑p ATKSLGSyAPGPRSR
S94 SyAPGPRSRSPSLNR
S98 GPRSRSPSLNRLGGA
S121 PPHWHVGSPFTPGAN
Y145‑p PGPRRKLySAVPGRL
S232 FRHYTVGSYDSFDAA
Y233 RHYTVGSYDSFDAAS
S235 YTVGSYDSFDAASDC