a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 220.127.116.11; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Tec family
Cellular Component: cytosol; extrinsic to internal side of plasma membrane
Molecular Function: ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity
Biological Process: apoptosis; cell structure disassembly during apoptosis; innate immune response; mesoderm development; NK T cell differentiation; programmed cell death; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.