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Protein Page:
FLOT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FLOT1 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasmic vesicle; early endosome; endosome; flotillin complex; focal adhesion; integral to membrane; lamellipodium; lipid raft; lysosomal membrane; membrane; microtubule organizing center; plasma membrane; signalosome; uropod
Molecular Function: protease binding; protein binding; protein heterodimerization activity
Biological Process: dsRNA transport; extracellular matrix disassembly; lipid raft formation; positive regulation of cytokine production; positive regulation of endocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of interferon-beta production; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of skeletal muscle development; positive regulation of synaptic transmission, dopaminergic; positive regulation of toll-like receptor 3 signaling pathway; protein homooligomerization; regulation of receptor internalization; regulation of toll-like receptor 4 signaling pathway
Reference #:  O75955 (UniProtKB)
Alt. Names/Synonyms: FLOT1; flotillin 1; Flotillin-1; integral membrane component of caveolae
Gene Symbols: FLOT1
Molecular weight: 47,355 Da
Basal Isoelectric point: 7.08  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FLOT1

Protein Structure Not Found.


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Sites Implicated In
endocytosis, altered: Y160‑p
molecular association, regulation: Y56‑p, Y149‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S19‑p VVSGFCRsPPVMVAG
0 1 K51‑ub NTLTLNVkSEKVyTR
1 0 Y56‑p NVkSEKVyTRHGVPI
0 1 K78 VKIQGQNKEMLAAAC
0 1 S128‑p YKDRQKFsEQVFKVA
1 0 Y149‑p MGISVVSyTLKDIHD
1 46 Y160‑p DIHDDQDyLHsLGKA
0 3 S163‑p DDQDyLHsLGKARTA
0 1 K166 DyLHsLGKARTAQVQ
0 1 K195‑ub GIREAKAkQEKVSAQ
0 186 Y203‑p QEKVSAQyLsEIEMA
0 1 S205‑p KVSAQyLsEIEMAKA
0 1 Y216‑p MAKAQRDyELKKAAy
0 13 Y223‑p yELKKAAyDIEVNTR
0 40 Y238‑p RAQADLAyQLQVAKT
0 1 K277 QEIARREKELEARVR
0 1 Y292‑p KPAEAERyKLERLAE
1 0 S315‑p QAEAEAAsVRMRGEA
0 2 Y348‑p KAEAFQLyQEAAQLD
0 2 S383‑p NKITLVSsGsGtMGA
0 7 S385‑p ITLVSsGsGtMGAAk
0 5 T387‑p LVSsGsGtMGAAkVT
0 17 K392‑ub sGtMGAAkVTGEVLD
0 1 S407‑p ILTRLPEsVERLTGV
0 1 K422 SISQVNHKPLRTA__
0 2 K422‑ub SISQVNHkPLRTA__
  mouse

 
S19 VVSGFCRSPPVMVAG
K51 NTLTLNVKSEKVYTR
Y56 NVKSEKVYTRHGVPI
K78‑ub VKIQGQNkEMLAAAC
S128 YKDRQKFSEQVFKVA
Y149 MGISVVSYTLKDIHD
Y160 DIHDDQDYLHsLGKA
S163‑p DDQDYLHsLGKARTA
K166 DYLHsLGKARTAQVQ
K195 GIREAKAKQEKVSAQ
C203 QEKVSAQCLSEIEMA
S205 KVSAQCLSEIEMAKA
Y216 MAKAQRDYELKKATY
Y223 YELKKATYDIEVNTR
Y238 RAQADLAYQLQVAKT
K277 QEIARREKELEARVR
Y292 KPAEAERYRLERLAE
S315 QAEAEAESVRMRGEA
Y348 KAEAFQMYQEAAQLD
S383 NKITLVSSGsGTMGA
S385‑p ITLVSSGsGTMGAAk
T387 LVSSGsGTMGAAkVT
K392‑ub sGTMGAAkVTGEVLD
S407 ILSRLPESVERLTGV
K423 ISQVNHNKPLRTA__
K423‑ub ISQVNHNkPLRTA__
  rat

 
S19 VVSGFCRSPPVMVAG
K51 NTLTLNVKSEKVYTR
Y56 NVKSEKVYTRHGVPI
K78 VKIQGQNKEMLAAAC
S128 YKDRQKFSEQVFKVA
Y149 MGISVVSYTLKDIHD
Y160‑p DIHDDQDyLHSLGkA
S163 DDQDyLHSLGkARTA
K166‑ac DyLHSLGkARTAQVQ
K195 GIREAKAKQEKVSAQ
C203 QEKVSAQCLSEIEMA
S205 KVSAQCLSEIEMAKA
Y216 MAKAQRDYELKKATY
Y223 YELKKATYDIEVNTR
Y238 RAQADLAYQLQVAKT
K277‑ac QEIARREkELEARVR
Y292 KPAEAERYRLERLAE
S315 QAEAEAESVRMRGEA
Y348 KAEAFQMYQEAAQLD
S383 NKITLVSSGSGTMGA
S385 ITLVSSGSGTMGAAK
T387 LVSSGSGTMGAAKVT
K392 SGTMGAAKVTGEVLD
S407 ILSRLPESVERLTGV
K423‑ac ISQVNHNkPLRTA__
K423 ISQVNHNKPLRTA__
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