Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PIK4CA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIK4CA Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, lipid; EC 2.7.1.67; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; plasma membrane
Molecular Function: 1-phosphatidylinositol 4-kinase activity; ATP binding; protein binding
Biological Process: phosphatidylinositol biosynthetic process; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; phospholipid metabolic process; signal transduction
Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis
Reference #:  P42356 (UniProtKB)
Alt. Names/Synonyms: FLJ16556; phosphatidylinositol 4-kinase 230; Phosphatidylinositol 4-kinase alpha; phosphatidylinositol 4-kinase, catalytic, alpha; phosphatidylinositol 4-kinase, type III, alpha; PI4-kinase alpha; PI4K-alpha; pi4K230; PI4KA; PIK4; PIK4CA; PtdIns-4-kinase alpha
Gene Symbols: PI4KA
Molecular weight: 236,830 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PIK4CA

Protein Structure Not Found.


STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y197‑p ISRAFGRysNMEEsL
0 1 S198‑p SRAFGRysNMEEsLL
0 1 S203‑p RysNMEEsLLSkLFP
0 2 K207‑ub MEEsLLSkLFPKIPP
0 32 S230‑p LEGVRRRsFNDFRsI
0 2 S236‑p RsFNDFRsILPsNLL
0 1 S240‑p DFRsILPsNLLTVCQ
0 12 T250‑p LTVCQEGtLKRKtss
0 1 K252 VCQEGtLKRKtssVs
0 14 T255‑p EGtLKRKtssVssIs
0 42 S256‑p GtLKRKtssVssIsQ
0 27 S257‑p tLKRKtssVssIsQV
0 6 S259‑p KRKtssVssIsQVsP
0 18 S260‑p RKtssVssIsQVsPE
0 13 S262‑p tssVssIsQVsPERG
0 26 S265‑p VssIsQVsPERGMPP
0 2 S429‑p DRIHNELsPLKLRCQ
0 1 K465 LCIKLSEKLQSKTSS
0 1 S502‑p RFPVVVHsVtPsLRD
0 1 T504‑p PVVVHsVtPsLRDFL
0 1 S506‑p VVHsVtPsLRDFLVI
0 1 K523 PVLVKLYKyHsQyHt
0 4 Y524‑p VLVKLYKyHsQyHtV
0 11 S526‑p VKLYKyHsQyHtVAG
0 57 Y528‑p LYKyHsQyHtVAGND
0 3 T530‑p KyHsQyHtVAGNDIK
0 3 N534 QyHtVAGNDIKISVT
0 1 T548‑p TNEHSEStLNVMSGK
0 4 K607 YISQESDKDAHLIPD
0 1 K607 YISQESDKDAHLIPD
0 1 K632 VALRDTPKVMEPILQ
0 73 Y691‑p VKASSVVySAtKDYK
0 1 T694‑p SSVVySAtKDYKDHG
0 2 S763‑p PALKASSsAGNLGVL
0 1 K838 PLLTFPSKEPLRSVL
0 4 Y847‑p PLRSVLQyNSAMkND
0 2 K852‑ub LQyNSAMkNDTVTPA
0 1 Y901‑p LSVYRLEyMRVLRst
0 2 S907‑p EyMRVLRstDPDRFQ
0 2 T908‑p yMRVLRstDPDRFQV
0 1 Y919‑p RFQVMFCyFEDKAIQ
0 1 K988‑ac RIRRVADkYLSGLVD
0 29 Y1031‑p DIHKDQPyyDIPDAP
0 4 Y1032‑p IHKDQPyyDIPDAPY
0 1 T1046 YRITVPDTYEARESI
0 1 K1077‑ub KWAPTVTkSHLQEYL
0 252 Y1154‑p NRYAGEVyGMIRFSG
0 1 K1336‑ub SLNIGGAkGSMNRHV
0 2 T1369‑p ADVVPNAtIRNVLRE
0 4 S1424 DKKYLTASQLVPPDN
0 23 S1436‑p PDNQDTRsNLDITVG
0 1 S1444‑p NLDITVGsRQQATQG
0 1 T1455‑p ATQGWINtYPLSSGM
0 1 K1473 SKKSGMSKKTNRGSQ
0 1 K1474 KKSGMSKKTNRGSQL
0 1 K1483 NRGSQLHKYYMKRRT
0 1 K1563 VQLPARFKNTEAIGN
0 1 Y1663‑p QIVQALRyDKMGYVR
0 1 Y1672‑p KMGYVREyILWAAsK
0 1 S1678‑p EyILWAAsKSQLLAH
0 4 K1749‑ub TNVSAIIkPYPKGDE
0 1 K1759 PKGDERKKACLSALS
0 1 Y1789‑p AIVLDIDyKSGTPMQ
0 1 T1793 DIDyKSGTPMQSAAK
0 1 Y1803‑p QSAAKAPyLAKFKVK
0 1 K1806 AKAPyLAKFKVKRCG
0 3 S1828‑p GLRCRSDsEDECSTQ
0 1 Y1884‑p LDLFVFPyRVVATAP
0 1 S2087‑p SCFLSNRsRtyDMIQ
0 1 T2089‑p FLSNRsRtyDMIQYY
0 2 Y2090‑p LSNRsRtyDMIQYYQ
  mouse

 
Y200 ISRSFGRYSNSEESL
S201 SRSFGRYSNSEESLL
S206 RYSNSEESLLSkLFP
K210‑ub SEESLLSkLFPKVSP
S233‑p LEGVRRRsFNDFRSI
S239 RsFNDFRSILPSNLL
S243 DFRSILPSNLLTVCQ
T253‑p LTVCQEGtLkRKtss
K255‑ub VCQEGtLkRKtssVs
T258‑p EGtLkRKtssVssIs
S259‑p GtLkRKtssVssIsQ
S260‑p tLkRKtssVssIsQV
S262‑p kRKtssVssIsQVsP
S263‑p RKtssVssIsQVsPE
S265‑p tssVssIsQVsPERG
S268‑p VssIsQVsPERGIPP
S432 DRIHSEMSPLKLRCQ
K468 LCIKLSEKLQSKTSS
S505 RFPVVVHSVTPSLRD
T507 PVVVHSVTPSLRDFL
S509 VVHSVTPSLRDFLVI
K526 PVLVKLYKYHSQYHT
Y527 VLVKLYKYHSQYHTV
S529 VKLYKYHSQYHTVAG
Y531 LYKYHSQYHTVAGsD
T533 KYHSQYHTVAGsDIK
S537‑p QYHTVAGsDIKISVT
T551 TNEHSESTLNVLPGK
K610‑ac YISQESDkDAHLIPD
K610‑ub YISQESDkDAHLIPD
K635‑ub VALRDTPkVMEPILQ
Y694 VKASSVVYSATKDYK
T697 SSVVYSATKDYKDHG
S766 PALKASSSAGNLGVL
K841‑ub PLLTFPSkEPLRSVL
Y850 PLRSVLQYNSAMkND
K855‑ub LQYNSAMkNDTVTPA
Y904 LSVYRLEYMRVLRst
S910‑p EYMRVLRstDPDRFQ
T911‑p YMRVLRstDPDRFQV
Y922 RFQVMFCYFEDKAIQ
K991 RIRRVADKYLSGLVD
Y1034‑p DIHKDQPyYDIPDAP
Y1035 IHKDQPyYDIPDAPY
T1049‑p YRITVPDtYEARESI
K1080 KWAPTVTKSHLQEYL
H1157 NRYAGEVHGMIRFSG
R1339 SLNIGGARGSMNRHV
T1372‑p ADVVPNAtIRNVLRE
S1427‑p DKKYLTAsQLVPPDN
S1439‑p PDNQDTRsNLDITVG
S1447 NLDITVGSRQQATQG
T1458 ATQGWINTYPLSSGM
K1476‑m1 SKKSGMSkkTNRGSQ
K1477‑m1 KKSGMSkkTNRGSQL
K1486 NRGSQLHKYYMKRRT
K1566‑ub VQLPARFkNTEAIGN
Y1666 QIVQALRYDKMGYVR
Y1675 KMGYVREYILWAAAK
A1681 EYILWAAAKSQLLAH
K1752‑ub TNVSAIIkPYPKGDE
K1762‑ub PKGDERKkACLSALS
Y1792 AIVLDIDYKSGtPMQ
T1796‑p DIDYKSGtPMQSAAK
Y1806 QSAAKAPYLAKFKVK
K1809 AKAPYLAKFKVKRCG
A1831 GLQCRSDAEDECFSQ
Y1887 LDLFVFPYRVVATAP
S2090 NCFLSNRSRTYDMIQ
T2092 FLSNRSRTYDMIQYY
Y2093 LSNRSRTYDMIQYYQ
  rat

 
Y139 ISKSFGRYSNSEESL
S140 SKSFGRYSNSEESLL
S145 RYSNSEESLLSKLFP
K149 SEESLLSKLFPKVPP
S172‑p LEGVRRRsFNDFRSI
S178 RsFNDFRSILPSNLL
S182 DFRSILPSNLLTVCQ
T192 LTVCQEGTLKRKtss
K194 VCQEGTLKRKtssVS
T197‑p EGTLKRKtssVSsIS
S198‑p GTLKRKtssVSsISQ
S199‑p TLKRKtssVSsISQV
S201 KRKtssVSsISQVsP
S202‑p RKtssVSsISQVsPE
S204 tssVSsISQVsPERG
S207‑p VSsISQVsPERGMPP
S371 DRIHSEMSPLKLRCQ
K407‑ac LCIKLSEkLQSKTSS
S444 RFPVVVHSVTPSLRD
T446 PVVVHSVTPSLRDFL
S448 VVHSVTPSLRDFLVI
K465‑ac PVLVKLYkYHSQYHT
Y466 VLVKLYkYHSQYHTV
S468 VKLYkYHSQYHTVAG
Y470 LYkYHSQYHTVAGSD
T472 kYHSQYHTVAGSDIK
S476 QYHTVAGSDIKISVT
T490 TNEHSESTLNVLPGK
K549‑ac YISQESDkDAHLIPD
K549 YISQESDKDAHLIPD
K574 VALRDTPKVMEPILQ
Y630 VKASSVVYSATKDYK
T633 SSVVYSATKDYKDHG
S702 PALKASSSAGNLGVL
K777 PLLTFPSKEPLRSVL
Y786 PLRSVLQYNSAMKND
K791 LQYNSAMKNDTVTPA
Y840 LSVYRLEYMRVLRST
S846 EYMRVLRSTDPDRFQ
T847 YMRVLRSTDPDRFQV
Y858 RFQVMFCYFEDKAIQ
K927 RIRRVADKYLSGLVD
Y970 DIHKDQPYYDIPDAP
Y971 IHKDQPYYDIPDAPY
T985 YRITVPDTYEARESI
K1016 KWAPTVTKSHLQEYL
H1093 NRYAGEVHGMIRFSG
R1275 SLHIGGARGSMNRHV
T1308 ADVVPNATIRNVLRE
S1363 DKKYLTASQLVPPDN
S1375‑p PDNQDTRsNLDITVG
S1383 NLDITVGSRQQATQG
T1394 ATQGWINTYPLSSGM
K1412 SKKSGMSKKTNRGSQ
K1413 KKSGMSKKTNRGSQL
K1422‑ac NRGSQLHkYYMKRRT
K1502 VQLPARFKNTEAIGN
Y1602 QIVQALRYDKMGYVR
Y1611 KMGYVREYILWAAAK
A1617 EYILWAAAKSQLLAH
K1688 TNVSAIIKPYPKGDE
K1698 PKGDERKKACLSALS
Y1728 AIVLDIDYKSGTPMQ
T1732 DIDYKSGTPMQSAAK
Y1742 QSAAKAPYLAkFKVK
K1745‑ac AKAPYLAkFKVKRCG
T1767 GLQCRSDTEDECRRQ
Y1823 LDLFVFPYRVVATAP
S2026 NCFLSNRSRTYDMIQ
T2028 FLSNRSRTYDMIQYY
Y2029 LSNRSRTYDMIQYYQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.