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Protein Page:
ANXA5 (human)

Overview
ANXA5 a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Calcium-binding; Inhibitor; Lipid-binding
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: cytoplasm; focal adhesion; intracellular; membrane
Molecular Function: calcium-dependent phospholipid binding; phospholipase inhibitor activity; phospholipid binding; protein binding
Biological Process: negative regulation of apoptosis; positive regulation of defense response to virus by host; signal transduction
Disease: Pregnancy Loss, Recurrent, Susceptibility To, 3
Reference #:  P08758 (UniProtKB)
Alt. Names/Synonyms: Anchorin CII; Annexin A5; Annexin V; Annexin-5; ANX5; anxa 5; ANXA5; Calphobindin I; CBP-I; Endonexin II; ENX2; Lipocortin V; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; PP4; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha
Gene Symbols: ANXA5
Molecular weight: 35,937 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Select Structure to View Below

ANXA5

Protein Structure Not Found.
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