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Protein Page:
DOK1 (human)

Overview
DOK1 a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: protein binding
Biological Process: cell surface receptor linked signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; signal transduction
Reference #:  Q99704 (UniProtKB)
Alt. Names/Synonyms: Docking protein 1; docking protein 1 (downstream of tyrosine kinase 1); docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK1; Downstream of tyrosine kinase 1; MGC117395; MGC138860; p62(dok); P62DOK; pp62
Gene Symbols: DOK1
Molecular weight: 52,392 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DOK1

Protein Structure Not Found.
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