a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. Note: This description may include information from UniProtKB.
Molecular Function: actin binding; enzyme binding; leucine zipper domain binding; protein binding; protein kinase C binding; protein phosphatase 1 binding; transcription corepressor activity
Biological Process: actin filament bundle formation; apoptosis; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; interleukin-2 biosynthetic process; negative regulation of B cell proliferation; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of amyloid precursor protein biosynthetic process; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of phosphoprotein phosphatase activity; response to iron(II) ion; response to lipopolysaccharide; response to wounding; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.