a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 22.214.171.124; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; EGFR family
Molecular Function: ATP binding; growth factor binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity; transmembrane receptor activity
Biological Process: activation of MAPKK activity; axon guidance; cranial nerve development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; nerve growth factor receptor signaling pathway; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of phosphoinositide 3-kinase cascade; Ras protein signal transduction; regulation of cell proliferation; Schwann cell differentiation; signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.