Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
HER3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HER3 a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; EGFR family
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular space; integral to plasma membrane; intracellular; lateral plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; growth factor binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity; transmembrane receptor activity
Biological Process: activation of MAPKK activity; axon guidance; cranial nerve development; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; nerve growth factor receptor signaling pathway; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of phosphoinositide 3-kinase cascade; Ras protein signal transduction; regulation of cell proliferation; Schwann cell differentiation; signal transduction; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing
Disease: Lethal Congenital Contracture Syndrome 2
Reference #:  P21860 (UniProtKB)
Alt. Names/Synonyms: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Gene Symbols: ERBB3
Molecular weight: 148,098 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HER3

Protein Structure Not Found.


STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
carcinogenesis, induced: Y1289‑p
cell growth, altered: Y1289‑p
molecular association, regulation: Y1054‑p, Y1197‑p, Y1199‑p, Y1222‑p, Y1260‑p, Y1262‑p, Y1276‑p, Y1289‑p, Y1328‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T640‑p TLVLIGKtHLTMALT
0 1 Y680‑p NKRAMRRyLERGEsI
0 42 S686‑p RyLERGEsIEPLDPs
0 1 S693‑p sIEPLDPsEKANKVL
0 1 K695 EPLDPsEKANKVLAR
0 1 S717‑p RKLKVLGsGVFGTVH
0 1 K736‑m1 IPEGESIkIPVCIKV
0 1 K736 IPEGESIKIPVCIKV
0 1 S844‑p ARNVLLKsPsQVQVA
0 1 S846‑p NVLLKsPsQVQVADF
0 1 K864 DLLPPDDKQLLysEA
0 3 Y868‑p PDDKQLLysEAKTPI
0 1 S869‑p DDKQLLysEAKTPIK
1 1 T873 LLysEAKTPIKWMAL
0 11 S982‑p YLVIKREsGPGIAPG
0 1 I986 KREsGPGIAPGPEPH
0 1 T996‑p GPEPHGLtNKKLEEV
3 22 Y1054‑p LLSPSSGyMPMNQGN
0 2 S1083‑p ERCPRPVsLHPMPRG
0 1 A1093 PMPRGCLAsESSEGH
0 2 S1094‑p MPRGCLAsESSEGHV
0 1 S1097 GCLAsESSEGHVTGs
0 1 S1104‑p SEGHVTGsEAELQEK
0 1 S1113‑p AELQEKVsMCRSRSR
1 2 S1123 RSRSRSRSPRPRGDS
0 8 Y1132‑p RPRGDSAyHSQRHSL
0 2 S1147‑p LTPVTPLsPPGLEEE
0 69 Y1159‑p EEEDVNGyVMPDtHL
0 4 T1164‑p NGyVMPDtHLKGTPS
5 27 Y1197‑p EEDEDEEyEyMNRRR
2 9 Y1199‑p DEDEEyEyMNRRRRH
0 1 S1207‑p MNRRRRHsPPHPPRP
0 1 S1215‑p PPHPPRPsSLEELGy
3 1 Y1222‑p sSLEELGyEYMDVGS
3 16 Y1260‑p GTTPDEDyEyMNRQR
2 3 Y1262‑p TPDEDyEyMNRQRDG
3 59 Y1276‑p GGGPGGDyAAMGACP
0 1 S1285‑p AMGACPAsEQGyEEM
18 127 Y1289‑p CPAsEQGyEEMRAFQ
0 133 Y1307‑p HQAPHVHyARLKtLR
0 1 T1312‑p VHyARLKtLRsLEAt
0 2 S1315‑p ARLKtLRsLEAtDSA
0 1 T1319‑p tLRsLEAtDSAFDNP
3 214 Y1328‑p SAFDNPDyWHsRLFP
0 2 S1331‑p DNPDyWHsRLFPKAN
0 1 K1336 WHsRLFPKANAQRT_
0 1 - gap
0 1 - gap
4561 : Phospho-HER3/ErbB3 (Tyr1197) (C56E4) Rabbit mAb
4784 : Phospho-HER3/ErbB3 (Tyr1222) (50C2) Rabbit mAb
  HER3 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T169‑p DDDPRLLtLSASsKV
S174‑p LLtLSASsKVPVTLA
  HER3 iso4  
T581 TLVLIGKTHLTMALT
Y621 NKRAMRRYLERGESI
S627 RYLERGESIEPLDPS
S634 SIEPLDPSEKANKVL
K636 EPLDPSEKANKVLAR
S658 RKLKVLGSGVFGTVH
K677 IPEGESIKIPVCIKV
K677 IPEGESIKIPVCIKV
S785 ARNVLLKSPSQVQVA
S787 NVLLKSPSQVQVADF
K805 DLLPPDDKQLLYSEA
Y809 PDDKQLLYSEAKTPI
S810 DDKQLLYSEAKTPIK
T814 LLYSEAKTPIKWMAL
S923 YLVIKRESGPGIAPG
I927 KRESGPGIAPGPEPH
T937 GPEPHGLTNKKLEEV
Y995 LLSPSSGYMPMNQGN
S1024 ERCPRPVSLHPMPRG
A1034 PMPRGCLASESSEGH
S1035 MPRGCLASESSEGHV
S1038 GCLASESSEGHVTGS
S1045 SEGHVTGSEAELQEK
S1054 AELQEKVSMCRSRSR
S1064 RSRSRSRSPRPRGDS
Y1073 RPRGDSAYHSQRHSL
S1088 LTPVTPLSPPGLEEE
Y1100 EEEDVNGYVMPDTHL
T1105 NGYVMPDTHLKGTPS
Y1138 EEDEDEEYEYMNRRR
Y1140 DEDEEYEYMNRRRRH
S1148 MNRRRRHSPPHPPRP
S1156 PPHPPRPSSLEELGY
Y1163 SSLEELGYEYMDVGS
Y1201 GTTPDEDYEYMNRQR
Y1203 TPDEDYEYMNRQRDG
Y1217 GGGPGGDYAAMGACP
S1226 AMGACPASEQGYEEM
Y1230 CPASEQGYEEMRAFQ
Y1248 HQAPHVHYARLKTLR
T1253 VHYARLKTLRSLEAT
S1256 ARLKTLRSLEATDSA
T1260 TLRSLEATDSAFDNP
Y1269 SAFDNPDYWHSRLFP
S1272 DNPDYWHSRLFPKAN
K1277 WHSRLFPKANAQRT_
- gap
- gap
  mouse

 
S638 GQAEVLMSKPHLVIA
Y678 NKRAMRRYLERGEsI
S684‑p RYLERGEsIEPLDPS
S691 sIEPLDPSEkANKVL
K693‑ub EPLDPSEkANKVLAR
S715‑p RKLKVLGsGVFGTVH
K734 IPEGESIKIPVCIKV
K734‑ub IPEGESIkIPVCIKV
S842 LRNVMLKSPSQVQVA
S844 NVMLKSPSQVQVADF
K862‑ub DLLPPDDkQLLHSEA
H866 PDDkQLLHSEAKTPI
S867 DDkQLLHSEAKTPIK
T871 LLHSEAKTPIKWMAL
S980‑p YLVIKRAsGPGIPPA
I984 KRAsGPGIPPAAEPS
S994 AAEPSALSTKELQDA
Y1051 LLSPSSGYMPMNQSN
S1080‑p EQFSRPIsLHPIPRG
T1090‑p PIPRGRQtsESsEGH
S1091‑p IPRGRQtsESsEGHV
S1094‑p GRQtsESsEGHVTGS
S1101 sEGHVTGSEAELQER
S1110 AELQERVSMCRSRSR
S1120‑p RSRSRSRsPRPRGDS
Y1129 RPRGDSAYHSQRHSL
S1144 LTPVTPLSPPGLEEE
Y1156‑p EEEDGNGyVMPDTHL
T1161 NGyVMPDTHLRGTSS
Y1194 EEDEDEEYEYMNRKR
Y1196 DEDEEYEYMNRKRRG
S1204 MNRKRRGSPARPPRP
G1212 PARPPRPGSLEELGY
Y1219 GSLEELGYEYMDVGS
Y1257 GTTPDEDYEyMNRRR
Y1259‑p TPDEDYEyMNRRRGA
Y1273 AGGSGGDYAAMGACP
A1282 AMGACPAAEQGyEEM
Y1286‑p CPAAEQGyEEMRAFQ
Y1304 HQAPHVRYARLKtLR
T1309‑p VRYARLKtLRsLEAT
S1312‑p ARLKtLRsLEATDSA
T1316 tLRsLEATDSAFDNP
Y1325‑p SAFDNPDyWHsRLFP
S1328‑p DNPDyWHsRLFPkAN
K1333‑ub WHsRLFPkANAQRI_
- gap
- gap
2842 : Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb
4791 : Phospho-HER3/ErbB3 (Tyr1289) (21D3) Rabbit mAb
8017 : Phospho-HER3/ErbB3 (Tyr1328) Antibody
14525 : Phospho-HER3/ErbB3 (Tyr1328) (E1J1T) Rabbit mAb
  rat

 
S638 GQAEVLMSKPHLVIA
Y678 NKRAMRRYLERGEsI
S684‑p RYLERGEsIEPLDPS
S691 sIEPLDPSEKANKVL
K693 EPLDPSEKANKVLAR
S715 RKLKVLGSGVFGTVH
K734 IPEGESIKIPVCIKV
K734 IPEGESIKIPVCIKV
S842 LRNVMLKSPSQVQVA
S844 NVMLKSPSQVQVADF
K862 DLLPPDDKQLLHSEA
H866 PDDKQLLHSEAKtPI
S867 DDKQLLHSEAKtPIK
T871‑p LLHSEAKtPIKWMAL
S980‑p YLVIKRAsGPGtPPA
T984‑p KRAsGPGtPPAAEPS
T994 AAEPSVLTTKELQEA
Y1051‑p LLSPSSGyMPMNQSS
S1080 EQFSRPISLHPIPRG
A1090 PIPRGRPASESSEGH
S1091 IPRGRPASESSEGHV
S1094 GRPASESSEGHVTGS
S1101 SEGHVTGSEAELQEK
S1110 AELQEKVSVCRSRSR
S1120‑p RSRSRSRsPRPRGDS
Y1129 RPRGDSAYHSQRHSL
S1144 LTPVTPLSPPGLEEE
Y1156 EEEDGNGYVMPDTHL
T1161 NGYVMPDTHLRGASS
Y1194‑p EEDEDEEyEYMNRKR
Y1196 DEDEEyEYMNRKRRG
S1204 MNRKRRGSPPRPPRP
G1212 PPRPPRPGSLEELGy
Y1219‑p GSLEELGyEYMDVGS
Y1257‑p GTTPDEDyEYMNRRR
Y1259 TPDEDyEYMNRRRGA
Y1273‑p AGGAGGDyAAMGACP
A1282 AMGACPAAEQGyEEM
Y1286‑p CPAAEQGyEEMRAFQ
Y1304 HHAPHVRYARLKTLR
T1309 VRYARLKTLRSLEAT
S1312 ARLKTLRSLEATDSA
T1316 TLRSLEATDSAFDNP
Y1325 SAFDNPDYWHSRLFP
S1328 DNPDYWHSRLFPKAN
K1333 WHSRLFPKANAQRT_
- gap
- gap
2842 : Phospho-HER3/ErbB3 (Tyr1289) (D1B5) Rabbit mAb
4791 : Phospho-HER3/ErbB3 (Tyr1289) (21D3) Rabbit mAb
8017 : Phospho-HER3/ErbB3 (Tyr1328) Antibody
14525 : Phospho-HER3/ErbB3 (Tyr1328) (E1J1T) Rabbit mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.