a TKL kinase of the LISK family that regulates actin dynamics. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. Phosphorylates cofilin, inhibiting its actin-depolymerizing activity. May contributes to Rho-induced reorganization of the actin cytoskeleton. Two alternative splice variants have been identified. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group