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Protein Page:
Fes (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Fes a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Tumor suppressor; Kinase, protein; TK group; Fer family
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; microtubule cytoskeleton
Molecular Function: non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; protein binding; protein-tyrosine kinase activity
Biological Process: cell proliferation; chemotaxis; epidermal growth factor receptor signaling pathway; innate immune response; multicellular organismal development; peptidyl-tyrosine phosphorylation; positive regulation of microtubule polymerization; positive regulation of myeloid cell differentiation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of cell proliferation; regulation of cell shape; regulation of mast cell degranulation
Reference #:  P07332 (UniProtKB)
Alt. Names/Synonyms: c-fes/fps protein; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog; feline sarcoma oncogene; FES; FPS; Oncogene FES, feline sarcoma virus; Proto-oncogene c-Fes; Proto-oncogene c-Fps; proto-oncogene tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase Fes/Fps
Gene Symbols: FES
Molecular weight: 93,497 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Fes

Protein Structure Not Found.
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Sites Implicated In
cell differentiation, altered: Y713‑p
cell growth, altered: Y713‑p
enzymatic activity, induced: Y713‑p
molecular association, regulation: Y713‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S64‑p GGQSRAIsPDsPISQ
0 1 S67‑p SRAIsPDsPISQSWA
0 1 S100‑p DLNSGPLsKLSLLIR
0 1 Y156‑p SAQAKRKyQEASKDK
0 16 Y261‑p RIQPEAEyQGFLRQY
0 1 S373‑p GLQVALCsQAKLQAQ
0 2 S408‑p LLQDDRHstsssEQE
0 2 T409‑p LQDDRHstsssEQER
0 2 S410‑p QDDRHstsssEQERE
0 2 S411‑p DDRHstsssEQEREG
0 2 S412‑p DRHstsssEQEREGG
0 4 T421‑p QEREGGRtPtLEILK
0 2 T423‑p REGGRtPtLEILKSH
0 1 S432 EILKSHISGIFRPKF
0 21 H456 PEVQKPLHEQLWyHG
0 2 Y461‑p PLHEQLWyHGAIPRA
0 1 S477‑p VAELLVHsGDFLVRE
0 1 T538 LSTQQPLTKKSGVVL
0 1 T595‑p AVKSCREtLPPDLKA
0 2 Y614‑p EARILKQySHPNIVR
6 119 Y713‑p REEADGVyAAsGGLR
0 1 S716‑p ADGVyAAsGGLRQVP
0 2 K725‑ub GLRQVPVkWTAPEAL
0 6 Y734‑p TAPEALNyGRYSSES
1 1 Y811‑p RPSFSTIyQELQSIR
  mouse

 
G64 GGQSWSSGPDSPVSQ
S67 SWSSGPDSPVSQSWA
S100 DLNSGPLSKLSVLIR
Y156 STQARRKYQEASKDK
Y261 RIQPEFEYLGFLRQY
S373 GLQIALCSQDKLQAQ
S408 LLQDDRHSTSSTEQE
T409 LQDDRHSTSSTEQER
S410 QDDRHSTSSTEQERE
S411 DDRHSTSSTEQEREG
T412 DRHSTSSTEQEREGG
T421‑p QEREGGRtPtLEILK
T423‑p REGGRtPtLEILKSH
S432‑p EILKSHFsGIFRPKF
Y456‑p PEVQKPLyEQLWyHG
Y461‑p PLyEQLWyHGAIPRA
S477 VAELLTHSGDFLVRE
T538‑p LSSQQPLtKKSGVVL
T595 AVKSCRETLPPDLKA
Y614 EARILKQYNHPNIVR
Y713‑p REEADGIyAASAGLR
S716 ADGIyAASAGLRQVP
K725 GLRQVPVKWTAPEAL
Y734 TAPEALNYGRYSSES
C811 RPSFSIICQELHSIR
  rat

 
G64 GGQSWSSGPDSPVSQ
S67 SWSSGPDSPVSQSWA
S100 DLNSGPLSKLSVLIR
Y156 SAQARRKYQEASKDK
Y261 RIQPEFEYLGFLRQY
N373 GLQVALCNQDKLQAQ
S408 LLQDDRHSTSSTEQE
T409 LQDDRHSTSSTEQER
S410 QDDRHSTSSTEQERD
S411 DDRHSTSSTEQERDG
T412 DRHSTSSTEQERDGG
T421 QERDGGRTPTLEIIK
T423 RDGGRTPTLEIIKSH
S432 EIIKSHFSGIFRPKF
H456 PEVQKPLHEQLWYHG
Y461 PLHEQLWYHGAIPRA
S477 VAELLTHSGDFLVRE
T538 LSSQQPLTKKSGVVL
T595 AVKSCRETLPPDLKA
Y614 EARILKQYNHPNIVR
Y713 REEADGIYAASAGLR
S716 ADGIYAASAGLRQVP
K725 GLRQVPVKWTAPEAL
Y734 TAPEALNYGRYSSES
C811 RPSFSTICQELQSIR
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