a protein kinase of the IKK family. Can mediate NFkB activation in response to certain growth factors. Forms a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; interferon type I production; negative regulation of interferon type I production; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of macroautophagy; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of interferon type I production; response to virus