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Protein Page:
NUMB (human)

Overview
NUMB Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cell-cell adherens junction; clathrin-coated vesicle; focal adhesion; plasma membrane
Molecular Function: protein binding
Biological Process: lateral ventricle development; neuroblast division in the subventricular zone; positive regulation of cell migration; positive regulation of neurogenesis
Reference #:  P49757 (UniProtKB)
Alt. Names/Synonyms: h-Numb; NUMB; numb homolog (Drosophila); Protein numb homolog; Protein S171; S171
Gene Symbols: NUMB
Molecular weight: 70,804 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NUMB

Protein Structure Not Found.
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