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Protein Page:
DNAJA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNAJA3 Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain). Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Apoptosis; Cell cycle regulation; Chaperone
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: actin filament; extrinsic to plasma membrane; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrion; neuromuscular junction; postsynaptic membrane
Molecular Function: protein binding
Biological Process: mitochondrion organization and biogenesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q96EY1 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; DNAJA3; DNJA3; FLJ45758; HCA57; Hepatocellular carcinoma-associated antigen 57; hTid-1; TID1; tumorous imaginal discs homolog; Tumorous imaginal discs protein Tid56 homolog
Gene Symbols: DNAJA3
Molecular weight: 52,489 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNAJA3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S40‑p GVVGAWLsRKLSVPA
0 3 K91‑ac HTSAPLAkEDYYQIL
0 3 Y113‑p QKEIKKAyyQLAKKY
0 2 Y114‑p KEIKKAyyQLAKKYH
0 1 K118 KAyyQLAKKYHPDTN
0 1 K130‑sc DTNKDDPkAKEkFSQ
0 2 K134‑ac DDPkAKEkFSQLAEA
0 1 Y142‑p FSQLAEAyEVLSDEV
0 1 K152‑ub LSDEVKRkQYDAYGs
0 1 S159‑p kQYDAYGsAGFDPGA
0 1 G168 GFDPGASGsQHSYWK
0 1 S169‑p FDPGASGsQHSYWKG
0 6 K242 TCERCNGKGNEPGTK
0 2 K385 PGTQTDQKIRMGGKG
0 6 S398‑p KGIPRINsYGYGDHy
0 1 Y399 GIPRINsYGYGDHyI
0 1 Y405‑p sYGYGDHyIHIKIRV
0 1 T417‑p IRVPKRLtSRQQSLI
  DNAJA3 iso2  
S40 GVVGAWLSRKLSVPA
K91 HTSAPLAKEDYYQIL
Y113 QKEIKKAYYQLAKKY
Y114 KEIKKAYYQLAKKYH
K118 KAYYQLAKKYHPDTN
K130 DTNKDDPKAKEKFSQ
K134 DDPKAKEKFSQLAEA
Y142 FSQLAEAYEVLSDEV
K152 LSDEVKRKQYDAYGS
S159 KQYDAYGSAGFDPGA
G168 GFDPGASGSQHSYWK
S169 FDPGASGSQHSYWKG
K242 TCERCNGKGNEPGTK
K385 PGTQTDQKIRMGGKG
S398 KGIPRINSYGYGDHY
Y399 GIPRINSYGYGDHYI
Y405 SYGYGDHYIHIKIRV
T417 IRVPKRLTSRQQSLI
  mouse

 
C40 GVVATSLCRKLCVSA
K91 HTSASLAKDDYYQIL
Y113 QKDIKKAYYQLAkKY
Y114 KDIKKAYYQLAkKYH
K118‑ac KAYYQLAkKYHPDTN
K130 DTNKDDPKAKEkFSQ
K134‑ac DDPKAKEkFSQLAEA
Y142 FSQLAEAYEVLSDEV
K152 LSDEVKRKQYDAYGS
S159 KQYDAYGSAGFDPGT
S168‑p GFDPGTSsSGQGYWR
S169 FDPGTSsSGQGYWRG
K242‑ac TCERCDGkGNEPGTK
K385‑ac AGIQTDQkIRLTGKG
S398‑p KGIPRINsyGYGDHY
Y399‑p GIPRINsyGYGDHYI
Y405 syGYGDHYIHIKIRV
S417 IRVPKRLSSRQQNLI
  rat

 
C40 GVVAASLCRKLCVSA
K91 HTSASLAKDDYYQIL
Y113‑p QKDIKKAyyQLAKKY
Y114‑p KDIKKAyyQLAKKYH
K118 KAyyQLAKKYHPDTN
K130 DTNKDDPKAKEkFSQ
K134‑ac DDPKAKEkFSQLAEA
Y142 FSQLAEAYEVLSDEV
K152 LSDEVKRKQYDAYGS
S159 KQYDAYGSAGFDPGA
S168 GFDPGASSSGQGYWR
S169 FDPGASSSGQGYWRG
K242 TCERCDGKGNEPGTK
K385‑ac AGIQTDQkIRLTGKG
S398 KGIPRINSYGYGDHY
Y399 GIPRINSYGYGDHYI
Y405 SYGYGDHYIHIKIRV
S417 IRVPKRLSSRQQNLI
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