a kinase of the DYRK family associated with the spliceosome and the kinetochore. It binds pre-mRNA splicing factors SFRS8, PRP6 and pinin. It is an essential kinase that associates with both the U5 snRNP and the N-CoR deacetylase complexes. It may help coordinate pre-mRNA splicing with chromatin remodeling and transcriptional regulation. PRP4 has recently been shown to be a kinetochore component that is necessary to establish a functional spindle assembly checkpoint, and is necessary for recruitment or maintenance of the checkpoint proteins RPS27, MAD1, and MAD2 at the kinetochores. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; EC 22.214.171.124; Kinase, protein; PRP4 subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome