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Protein Page:
VRK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VRK1 Serine/threonine kinase that phosphorylates Thr-18 of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Defects in VRK1 are the cause of pontocerebellar hypoplasia type 1 (PCH1); also called pontocerebellar hypoplasia with infantile spinal muscular atrophy or pontocerebellar hypoplasia with anterior horn cell disease. PCH1 is characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and anterior horn cell degeneration resembling infantile spinal muscular atrophy (SMA). Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; VRK family
Chromosomal Location of Human Ortholog: 14q32
Cellular Component: cytoplasm; cytosol; Golgi stack; nucleolus; nucleoplasm; nucleus
Molecular Function: histone serine kinase activity (H3-S10 specific); nucleosomal histone binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell shape
Disease: Pontocerebellar Hypoplasia, Type 1a
Reference #:  Q99986 (UniProtKB)
Alt. Names/Synonyms: MGC117401; MGC138280; MGC142070; PCH1; Serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1; VRK1
Gene Symbols: VRK1
Molecular weight: 45,476 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VRK1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cytoskeletal reorganization: S342‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K5‑sm ___MPRVkAAQAGRQ
0 1 K16‑ub AGRQSSAkRHLAEQF
0 1 S75‑p CVVKVEPsDNGPLFT
0 1 K85‑ub GPLFTELkFYQRAAk
0 1 K92‑sm kFYQRAAkPEQIQkW
0 1 K98‑ac AkPEQIQkWIRTRKL
0 1 K98‑ub AkPEQIQkWIRTRKL
0 2 K112‑ub LKYLGVPkYWGSGLH
0 1 K112‑sm LKYLGVPkYWGSGLH
0 1 K140‑ac RFGSDLQkIYEANAk
0 1 K140‑ub RFGSDLQkIYEANAk
0 1 K147‑ac kIYEANAkRFSRktV
0 1 K152‑sm NAkRFSRktVLQLsL
0 2 T153‑p AkRFSRktVLQLsLR
0 2 S158‑p RktVLQLsLRILDIL
0 3 K188‑ub SNLLLNYkNPDQVYL
0 1 Y194 YkNPDQVYLVDYGLA
0 1 K211‑ac YCPEGVHkEYKEDPK
0 1 K269‑sm EDNLKDPkYVRDSkI
0 1 K275‑sm PkYVRDSkIRYRENI
0 1 K293‑ac MDKCFPEkNKPGEIA
0 4 K301‑ub NKPGEIAkYMETVkL
0 1 K307‑sm AkYMETVkLLDYTEk
0 1 K314‑ub kLLDYTEkPLYENLR
0 3 K329‑ub DILLQGLkAIGSkDD
0 1 K334‑ac GLkAIGSkDDGkLDL
0 1 K338‑sm IGSkDDGkLDLsVVE
2 5 S342‑p DDGkLDLsVVENGGL
0 1 K350‑sm VVENGGLkAKTItKK
3 0 T355‑p GLkAKTItKKRKKEI
0 4 S376‑p GVEDTEWsNtQtEEA
0 18 T378‑p EDTEWsNtQtEEAIQ
0 8 T380‑p TEWsNtQtEEAIQTR
0 1 - gap
  mouse

 
K5 ___MPRVKAAQAGRP
K16 AGRPGPAKRRLAEQF
S75 CVVKVEPSDNGPLFT
K85 GPLFTELKFYQRAAK
K92 KFYQRAAKPEQIQKW
K98 AKPEQIQKWIRTHKL
K98 AKPEQIQKWIRTHKL
K112 LKYLGVPKYWGSGLH
K112 LKYLGVPKYWGSGLH
K140 RFGSDLQKIYEANAK
K140 RFGSDLQKIYEANAK
K147 KIYEANAKRFSRKTV
K152 NAKRFSRKTVLQLSL
T153 AKRFSRKTVLQLSLR
S158 RKTVLQLSLRILDIL
K188 SNLLLSHKNPDQVyL
Y194‑p HKNPDQVyLVDYGLA
K211 YCPDGVHKEYKEDPK
N269 EDNLKDPNYVRDSKI
K275 PNYVRDSKIRYRDNV
K293 MEKCFPEKNKPGEIA
K301 NKPGEIAKYMESVKL
K307 AKYMESVKLLEYTEK
K314 KLLEYTEKPLYQNLR
K329 DILLQGLKAIGSKDD
K334 GLKAIGSKDDGKLDF
K338 IGSKDDGKLDFSAVE
S342 DDGKLDFSAVENGSV
K350 AVENGSVKTRPAsKK
S355‑p SVKTRPAsKKRKKEA
S376 AVEDMECSDTQVQEA
T378 EDMECSDTQVQEAAQ
V380 MECSDTQVQEAAQTR
S411‑p AGCSSSDsSRRQQHL
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