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Protein Page:
PSMD10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMD10 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex; Protease
Chromosomal Location of Human Ortholog: Xq22.3
Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; nucleoplasm; nucleus; proteasome complex; proteasome regulatory particle
Molecular Function: protein binding; transcription factor binding
Biological Process: activation of MAPKK activity; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; apoptosis; axon guidance; cytoplasmic sequestering of NF-kappaB; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G1/S transition of mitotic cell cycle; gene expression; inhibition of NF-kappaB transcription factor; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; mitotic cell cycle; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPKKK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; nerve growth factor receptor signaling pathway; polyamine metabolic process; positive regulation of cell growth; positive regulation of cyclin-dependent protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; programmed cell death; protein polyubiquitination; Ras protein signal transduction; regulation of amino acid metabolic process; regulation of apoptosis; regulation of mRNA stability; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction
Reference #:  O75832 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S non-ATPase subunit 10; PSD10; PSMD10
Gene Symbols: PSMD10
Molecular weight: 24,428 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMD10

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 15 K23‑ub SGKLEELkESILADk
0 56 K30‑ub kESILADkSLATRTD
0 1 S75‑p DKDDAGWsPLHIAAS
0 3 K90‑ub AGRDEIVkALLGKGA
0 5 Y112 NGCTPLHYAASKNRH
0 21 Y138‑p NPDAKDHyEATAMHR
0 1 K153‑ub AAAKGNLkMIHILLY
0 1 Y199‑p VSQGASIyIENKEEK
0 1 T207‑p IENKEEKtPLQVAkG
0 1 K213‑ub KtPLQVAkGGLGLIL
0 3 K221‑ac GGLGLILkRMVEG__
0 1 K221‑ub GGLGLILkRMVEG__
0 2 - gap
  mouse

 
K23 SGKLDELKERILADk
K30‑ub KERILADkSLATRTD
S75 DKDDAGWSPLHIAAS
K90 AGRDEIVKALLVKGA
Y112‑p NGCTPLHyAASKNRH
Y138‑p NPDAKDHyDATAMHR
K153 AAAKGNLKMVHILLF
Y199 VTQGASIYIENKEEK
T207 IENKEEKTPLQVAKG
K213 KTPLQVAKGGLGLIL
K221 GGLGLILKRLAESEE
K221 GGLGLILKRLAESEE
S230‑p LAESEEAsM______
  rat

 
K23 NGKLDELKESILADK
K30 KESILADKSLATRTD
S75 EKDDAGWSPLHIAAS
K90 AGRDEIVKALLIKGA
Y112 NGCTALHYAASKNRH
Y138 NPDAKNHYDATAMHR
K153 AAAKGNLKMVHILLF
Y199 VTQGASIYIENKEEK
T207 IENKEEKTPLQVAKG
K213 KTPLQVAKGGLGLIL
K221 GGLGLILKRIAESEE
K221 GGLGLILKRIAESEE
S230 IAESEEASM______
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