a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; MLK family; MLK subfamily
Molecular Function: ATP binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: activation of JNK activity; activation of JNKK activity; apoptosis; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.