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Protein Page:
MLK1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLK1 a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 14q24.2
Cellular Component: intracellular
Molecular Function: ATP binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: activation of JNK activity; activation of JNKK activity; apoptosis; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Reference #:  P80192 (UniProtKB)
Alt. Names/Synonyms: M3K9; MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); MLK1; PRKE1
Gene Symbols: MAP3K9
Molecular weight: 121,895 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLK1

Protein Structure Not Found.


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Sites Implicated In
activity, induced: T312‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y110‑p VGIFPSNyVTPRSAF
1 0 T312‑p TKMSAAGtYAWMAPE
0 1 T452‑p RTWEEELtRAALQQK
0 3 S519‑p LKDGNRIsLPSDFQH
0 3 S533‑p HKFTVQAsPtMDKRK
0 3 T535‑p FTVQAsPtMDKRKSL
0 2 S547 KSLINSRSsPPAsPT
0 3 S548‑p SLINSRSsPPAsPTI
0 11 S552‑p SRSsPPAsPTIIPRL
0 2 T554 SsPPAsPTIIPRLRA
0 2 T565‑p RLRAIQLtPGESSKT
0 1 K593 EEEKRAPKkkGRTWG
0 1 K594‑ac EEKRAPKkkGRTWGP
0 1 K595‑ac EKRAPKkkGRTWGPG
0 1 K607‑ac GPGTLGQkELASGDE
0 1 S616‑p LASGDEGsPQRREKA
0 4 S652‑p GYKQWSSsAPNLVKG
0 1 S693‑p GESRLQHsPsQSYLC
0 1 S695‑p SRLQHsPsQSYLCIP
0 1 S807‑p RSSRPRRstsPPsRK
0 1 T808‑p SSRPRRstsPPsRKL
0 1 S809‑p SRPRRstsPPsRKLF
0 2 S812‑p RRstsPPsRKLFKKE
0 1 T915‑p QPSSHRRtPsDGALK
0 3 S917‑p SSHRRtPsDGALKPE
0 2 S938‑p SPSSNGLsPSPGAGM
0 1 T948‑p PGAGMLKtPSPSRDP
  MLK1 iso4  
Y110 VGIFPSNYVTPRSAF
T312 TKMSAAGTYAWMAPE
T452 RTWEEELTRAALQQK
S519 LKDGNRISLPSDFQH
S533 HKFTVQASPTMDKRK
T535 FTVQASPTMDKRKSL
S547 KSLINSRSSPPASPT
S548 SLINSRSSPPASPTI
S552 SRSSPPASPTIIPRL
T554 SSPPASPTIIPRLRA
T565 RLRAIQLTPGESSKT
K593 EEEKRAPKKKGRTWG
K594 EEKRAPKKKGRTWGP
K595 EKRAPKKKGRTWGPG
K607 GPGTLGQKELASGDE
S616 LASGDEGSPQRREKA
S652 GYKQWSSSAPNLVKG
S707 GESRLQHSPSQSYLC
S709 SRLQHSPSQSYLCIP
S821 RSSRPRRSTSPPSRK
T822 SSRPRRSTSPPSRKL
S823 SRPRRSTSPPSRKLF
S826 RRSTSPPSRKLFKKE
T929 QPSSHRRTPSDGALK
S931 SSHRRTPSDGALKPE
S952 SPSSNGLSPSPGAGM
T962 PGAGMLKTPSPSRDP
  mouse

 
Y103 VGIFPSNYVTPRSAF
T305 TKMSAAGTYAWMAPE
T445 RTWEEELTRAALQQK
S512‑p LKDGNRIsLPSDFQH
S526 HKFTVQASPtMDKRK
T528‑p FTVQASPtMDKRKSL
S540‑p KSLISNRssPPAsPt
S541‑p SLISNRssPPAsPtI
S545‑p NRssPPAsPtIIPRL
T547‑p ssPPAsPtIIPRLRA
T558 RLRAIQLTPGESSKT
K586‑ub EEEKRAPkKKGRTWG
K587 EEKRAPkKKGRTWGP
K588 EKRAPkKKGRTWGPG
K600 GPGTLGQKELTSGDE
- gap
S622‑p GYKQWSSsAPNLGKG
S663 GENHQQHSPNQSYLC
N665 NHQQHSPNQSYLCIP
S777 RASRPRRSTSPPSRK
T778 ASRPRRSTSPPSRKL
S779 SRPRRSTSPPSRKLF
S782 RRSTSPPSRKLFKKE
T885 QPSGHRRTPSDGALK
S887 SGHRRTPSDGALKPT
S911 SPSSNGMSPSPGTGM
T921 PGTGMLKTPSPSRDP
  rat

 
Y103 VGIFPSNYVTPRSAF
T305 TKMSAAGTYAWMAPE
T445 RTWEEELTRAALQQK
S512 LKDGNRISLPSDFQH
S526‑p HKFTVQAsPTMDKRK
T528 FTVQAsPTMDKRKSL
S540 KSLISNRSSPPASPT
S541 SLISNRSSPPASPTI
S545 NRSSPPASPTIIPRL
T547 SSPPASPTIIPRLRA
T558 RLRAIQLTPGESSKT
K586 EEEKRAPKKKGRTWG
K587 EEKRAPKKKGRTWGP
K588 EKRAPKKKGRTWGPG
K600 GPGTLGQKELTSGDE
- gap
S622 GYKQWSSSAPNLGKG
S663 GENHLQHSPNQSYLC
N665 NHLQHSPNQSYLCIP
S777 RASRPRRSTSPPSRK
T778 ASRPRRSTSPPSRKL
S779 SRPRRSTSPPSRKLF
S782 RRSTSPPSRKLFKKE
T885 QPSGHRRTPSDGALK
S887 SGHRRTPSDGALKPA
S911 SPSSNGVSPGPGAGM
T921 PGAGMLKTPSPSRDP
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