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Protein Page:
DDX6 (human)

DDX6 an oncogenic ATP-dependent helicase of the DEAD box family. Interacts with argonaute proteins, Ago1 and Ago2, and is a general repressor of translation in human cells by miRNA-induced gene silencing. In the process of mRNA degradation, may play a role in mRNA decapping. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Oncoprotein; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; nucleus; stress granule
Molecular Function: ATP-dependent RNA helicase activity; helicase activity; protein binding; protein domain specific binding; RNA helicase activity
Biological Process: cytoplasmic mRNA processing body assembly; regulation of translation; RNA secondary structure unwinding; viral RNA genome packaging
Reference #:  P26196 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase p54; DDX6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD box protein 6; DEAD box-6; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD); FLJ36338; HLR2; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK
Gene Symbols: DDX6
Molecular weight: 54,417 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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