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Protein Page:
CK2A1 (human)

Overview
CK2A1 an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB). Note: This description may include information from UniProtKB.
Protein type: CK2 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: cytosol; nucleoplasm; nucleus; NuRD complex; PcG protein complex; plasma membrane; Sin3 complex
Molecular Function: Hsp90 protein binding; kinase activity; protein binding; protein N-terminus binding; protein serine/threonine kinase activity
Biological Process: negative regulation of caspase activity; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of protein catabolic process; positive regulation of Wnt receptor signaling pathway; protein amino acid phosphorylation; protein folding; signal transduction
Disease: Okur-chung Neurodevelopmental Syndrome
Reference #:  P68400 (UniProtKB)
Alt. Names/Synonyms: casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 subunit; Casein kinase II subunit alpha; CK II alpha; CK2 catalytic subunit alpha; CK2A1; CKII; CSK21; CSNK2A1; protein kinase CK2
Gene Symbols: CSNK2A1
Molecular weight: 45,144 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CK2A1

Protein Structure Not Found.
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