a transcriptional regulator central in Th2 cell differentiation. Inhibits breast cancer growth and pulmonary breast cancer metastasis. Represses INK4C transcription, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland. High GATA3 and low INK4C expression predicts a favorable patient outcome in luminal A type breast tumors. IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human T cells. GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness, and renal dysplasia) syndrome. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: chromatin binding; DNA binding; interleukin-2 receptor binding; protein binding; protein dimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding; zinc ion binding
Biological Process: anatomical structure formation; anatomical structure morphogenesis; axon guidance; blood coagulation; cell fate commitment; cell fate determination; cell maturation; chromatin remodeling; defense response; developmental growth; ear development; embryonic hemopoiesis; erythrocyte differentiation; gut development; heart development; humoral immune response; in utero embryonic development; innate immune response; inner ear morphogenesis; kidney development; lens development in camera-type eye; male gonad development; mesonephros development; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of mammary gland epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron migration; norepinephrine biosynthetic process; organ morphogenesis; parathyroid gland development; pharyngeal system development; phosphoinositide 3-kinase cascade; positive regulation of interleukin-4 production; positive regulation of protein kinase B signaling cascade; positive regulation of signal transduction; positive regulation of T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic development; pro-T cell differentiation; regulation of CD4-positive, alpha beta T cell differentiation; regulation of cytokine biosynthetic process; regulation of histone H3-K4 methylation; regulation of neuron apoptosis; response to drug; response to estrogen stimulus; response to ethanol; response to gamma radiation; response to virus; signal transduction; sympathetic nervous system development; T cell receptor signaling pathway; T-helper 2 cell differentiation; thymic T cell selection; thymus development; TOR signaling pathway; transcription from RNA polymerase II promoter; type IV hypersensitivity; uterus development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.