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Protein Page:
GATA3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GATA3 a transcriptional regulator central in Th2 cell differentiation. Inhibits breast cancer growth and pulmonary breast cancer metastasis. Represses INK4C transcription, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland. High GATA3 and low INK4C expression predicts a favorable patient outcome in luminal A type breast tumors. IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human T cells. GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness, and renal dysplasia) syndrome. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: nuclear chromatin; nucleolus; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding; protein binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: anatomical structure formation; anatomical structure morphogenesis; blood coagulation; cell fate commitment; cell fate determination; defense response; ear development; gut development; heart development; kidney development; male gonad development; mesonephros development; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of mammary gland epithelial cell proliferation; negative regulation of transcription, DNA-dependent; norepinephrine biosynthetic process; organ morphogenesis; pharyngeal system development; phosphoinositide 3-kinase cascade; positive regulation of interleukin-4 production; positive regulation of protein kinase B signaling cascade; positive regulation of signal transduction; positive regulation of T cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cytokine biosynthetic process; response to estrogen stimulus; response to virus; signal transduction; sympathetic nervous system development; T cell receptor signaling pathway; TOR signaling pathway; uterus development
Disease: Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Reference #:  P23771 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 3; GATA-binding factor 3; GATA3; HDR; MGC2346; MGC5199; MGC5445; Trans-acting T-cell-specific transcription factor GATA-3
Gene Symbols: GATA3
Molecular weight: 47,916 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA3

Protein Structure Not Found.
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Sites Implicated In
transcription, induced: S308‑p
activity, induced: S308‑p
protein degradation: T156‑p
ubiquitination: T156‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 S110‑p LGSHHTAsPWNLsPF
0 23 S115‑p TAsPWNLsPFSKTSI
1 0 T156‑p HLFTFPPtPPKDVsP
1 8 S162‑p PtPPKDVsPDPSLST
0 1 S172‑p PSLSTPGsAGSARQD
0 1 Y186‑p DEKECLKyQVPLPDS
0 1 S258 SRPKARSSTGrECVN
1 0 R261‑m2 KARSSTGrECVNCGA
0 1 T271‑p VNCGATStPLWRRDG
0 2 Y282‑p RRDGTGHyLCNACGL
0 3 Y290‑p LCNACGLyHkMNGQN
1 0 K292‑ac NACGLyHkMNGQNRP
1 0 K304‑ac NRPLIKPkRRLsAAR
3 0 S308‑p IKPkRRLsAARRAGT
1 0 K346‑ac NACGLYYkLHNINRP
0 1 K358 NRPLTMKKEGIQTRN
0 28 S369‑p QTRNRKMsSkSkkCk
0 1 K371‑ac RNRKMsSkSkkCkKV
0 1 K373‑ac RKMsSkSkkCkKVHD
0 1 K374‑ac KMsSkSkkCkKVHDs
0 1 K376‑ac sSkSkkCkKVHDsLE
0 3 S381‑p kCkKVHDsLEDFPKN
  GATA3 iso2  
S110 LGSHHTASPWNLSPF
S115 TASPWNLSPFSKTSI
T156 HLFTFPPTPPKDVSP
S162 PTPPKDVSPDPSLST
S172 PSLSTPGSAGSARQD
Y186 DEKECLKYQVPLPDS
S258‑p SRPKARSsTEGRECV
R262 ARSsTEGRECVNCGA
T272 VNCGATSTPLWRRDG
Y283 RRDGTGHYLCNACGL
Y291 LCNACGLYHKMNGQN
K293 NACGLYHKMNGQNRP
K305 NRPLIKPKRRLSAAR
S309 IKPKRRLSAARRAGT
K347 NACGLYYKLHNINRP
K359 NRPLTMKKEGIQTRN
S370 QTRNRKMSSKSKKCK
K372 RNRKMSSKSKKCKKV
K374 RKMSSKSKKCKKVHD
K375 KMSSKSKKCKKVHDS
K377 SSKSKKCKKVHDSLE
S382 KCKKVHDSLEDFPKN
  mouse

 
S109 LSSHHTASPWNLsPF
S114‑p TASPWNLsPFSKTSI
T155‑p HLFTFPPtPPKDVsP
S161‑p PtPPKDVsPDPSLST
S171‑p PSLSTPGsAGSARQD
Y185 DEKECLKYQVQLPDS
S257‑p SRPKARSsTEGRECV
R261 ARSsTEGRECVNCGA
T271 VNCGATSTPLWRRDG
Y282 RRDGTGHYLCNACGL
Y290 LCNACGLYHKMNGQN
K292 NACGLYHKMNGQNRP
K304 NRPLIKPKRRLsAAR
S308‑p IKPKRRLsAARRAGT
K346 NACGLYYKLHNINRP
K358‑ac NRPLTMKkEGIQTRN
S369 QTRNRKMSSKSKKCK
K371 RNRKMSSKSKKCKKV
K373 RKMSSKSKKCKKVHD
K374 KMSSKSKKCKKVHDA
K376 SSKSKKCKKVHDALE
A381 KCKKVHDALEDFPKS
  rat

 
S110 LSSHHTASPWNLSPF
S115 TASPWNLSPFSKTSI
T156 HLFTFPPTPPKDVsP
S162‑p PTPPKDVsPDPSLST
S172 PSLSTPGSAGSARQD
Y186 DEKECLKYQVQLPDS
S258 SRPKARSSTEGRECV
R262 ARSSTEGRECVNCGA
T272 VNCGATSTPLWRRDG
Y283 RRDGTGHYLCNACGL
Y291 LCNACGLYHKMNGQN
K293 NACGLYHKMNGQNRP
K305 NRPLIKPKRRLSAAR
S309 IKPKRRLSAARRAGT
K347 NACGLYYKLHNINRP
K359 NRPLTMKKEGIQTRN
S370 QTRNRKMSSKSKKCK
K372 RNRKMSSKSKKCKKV
K374 RKMSSKSKKCKKVHD
K375 KMSSKSKKCKKVHDA
K377 SSKSKKCKKVHDALE
A382 KCKKVHDALEDFPKS
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