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Protein Page:
STAT6 (rat)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT6 transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Cellular Component: cytoplasm; lipid raft; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: DNA binding; identical protein binding; protein phosphatase binding; sequence-specific DNA binding; signal transducer activity; transcription factor activity
Biological Process: cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; response to cytokine stimulus; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent
Reference #:  NP_001037715 (RefSeq)
Alt. Names/Synonyms: signal transducer and activator of transcription 6; STAT6
Gene Symbols: Stat6
Molecular weight: 93,870 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT6

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 S2 ______MSLWSLVSK
0 2 S8 MSLWSLVSKMSPEKL
1 0 R27 VDFPQHLRHLLAEWL
0 1 K94 IYQRDPLKLVATIRQ
0 1 K129 HRKQEELKFTTALGR
0 1 K277 TSSFLVEKQPPQVLK
0 1 K307 QFLGTSAKPPLVRAD
0 1 K319 RADMVTEKQARELSL
1 0 S407 LIQLQALSLPLVVIV
0 1 T525 FDGVLDLTKRCLRSY
0 2 K595 NIQPFSAKDLSIRSL
0 1 K619 LKNLYPKKPKDEAFR
0 1 K621 NLYPKKPKDEAFRSH
15 81 Y641‑p MGKDGRGyVSTTIKM
0 2 T645 GRGyVSTTIKMTVER
1 0 P702 IHSFQSIPLEESMSV
1 0 S751 SQEHAVSSPEPLLCS
  human

► Hide Isoforms
 
S2‑p ______MsLWGLVsK
S8‑p MsLWGLVsKMPPEKV
R27 VDFPQHLRHLLGDWL
K94 IYQRDPLKLVATFRQ
K129 HWKQEELKFKTGLRR
K277 TSCFLVEKQPPQVLK
K307‑ub RFLGAPAkPPLVRAD
K319‑ub RADMVTEkQARELSV
S407‑p PIQLQALsLPLVVIV
T525‑p FDGVLDLtKRCLRSY
K595‑ub NIQPFSAkDLSIRSL
K619 LKNLYPKKPKDEAFR
K621 NLYPKKPKDEAFRSH
Y641‑p MGKDGRGyVPAtIKM
T645‑p GRGyVPAtIKMTVER
S707‑p IPPYQGLsPEESVNV
S756‑p PQEHAVSsPDPLLCS
  STAT6 iso2  
- gap
- gap
- gap
- gap
- gap
K103 TSCFLVEKQPPQVLK
K133 RFLGAPAKPPLVRAD
K145 RADMVTEKQARELSV
S233 PIQLQALSLPLVVIV
T351 FDGVLDLTKRCLRSY
K421 NIQPFSAKDLSIRSL
K445 LKNLYPKKPKDEAFR
K447 NLYPKKPKDEAFRSH
Y467 MGKDGRGYVPATIKM
T471 GRGYVPATIKMTVER
S533 IPPYQGLSPEESVNV
S582 PQEHAVSSPDPLLCS
  mouse

 
S2 ______MSLWGLISK
S8 MSLWGLISKMSPEKL
R27‑me VDFPQRLrHLLADWL
K94‑ub IYQRDPLkLVATIRQ
K129‑ac HRKQEELkFTTALGR
K277‑ub TSSFLVEkQPPQVLK
K307 QFLGTSAKPPMVRAD
K319 RADMVTEKQARELSL
S407 LIQLQALSLPLVVIV
T525 FDGVLDLTKRCLRSY
K595‑ub NIQPFSAkDLSIRSL
K619‑ac LKNLYPKkPkDEAFR
K621‑ac NLYPKkPkDEAFRSH
Y641‑p MGKDGRGyVSTTIKM
T645 GRGyVSTTIKMTVER
- gap
S747 SQEHAVSSPEPMLCS
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