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Protein Page:
IRAK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; inflammatory response; inhibition of NF-kappaB transcription factor; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; protein amino acid phosphorylation; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Reference #:  O43187 (UniProtKB)
Alt. Names/Synonyms: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2; MGC150550
Gene Symbols: IRAK2
Molecular weight: 69,433 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IRAK2

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y4‑p ____MACyIyQLPSW
0 1 Y6‑p __MACyIyQLPSWVL
0 1 R50 RKIKSMERVQGVSIT
0 2 T137 GQPVRMATFPGPGss
0 2 P141 RMATFPGPGssPARA
0 1 S143‑p ATFPGPGssPARAHQ
0 1 S144‑p TFPGPGssPARAHQP
0 1 S172 LRSDLPTSSDSKDFS
0 1 S430‑p YLKDLLLsDIPsSTA
0 1 S434‑p LLLsDIPsSTAsLCS
0 1 S438‑p DIPsSTAsLCSRKTG
0 1 K443 TAsLCSRKTGVENVM
0 1 K461‑ac ICQKYLEkGAGRLPE
0 1 T508 ERLRGRETLLPWSGL
  mouse

 
Y4 ____MACYIYQLPSW
Y6 __MACYIYQLPSWVL
R50‑m1 RKIKSMErVQGVSIT
S136‑p VRPVKPRsLLDtGPI
T140‑p KPRsLLDtGPIMAGA
- gap
- gap
S168‑p LKTDAPDsPQSKYCS
S428 YLKDLLLSEIPNSTS
N432 LLLSEIPNSTSSVCS
S436 EIPNSTSSVCSRKTS
K441 TSSVCSRKTSMGKAV
K459 ICQRHVEKRAGLLPE
S506‑p EQLRGQLsLPWSRVS
  rat

 
Y4 ____MACYIYQLPSW
Y6 __MACYIYQLPSWVL
R50 RKIKSMERVQGVSIT
S136 GQPVKPCSFLSSGTT
S140 KPCSFLSSGTTMAGA
T142 CSFLSSGTTMAGAQQ
T143 SFLSSGTTMAGAQQQ
S172 LKTDVPDSLQSKYCS
S430 YLKDLLLSEIPSNTS
S434 LLLSEIPSNTSSVHS
S438 EIPSNTSSVHSRkTS
K443‑ub TSSVHSRkTSMGKVV
R461 ICQKHLERKAGLLPE
S508 EQLRGQLSLPWSRVS
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