Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; protein binding; retinoid X receptor binding; transcription factor activity
Biological Process: embryonic eye morphogenesis; embryonic hindlimb morphogenesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of programmed cell death; positive regulation of transcription from RNA polymerase II promoter; regulation of cell size; response to retinoic acid; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.