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Protein Page:
GATA6 (human)

Overview
GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q11.1-q11.2
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding
Biological Process: blood coagulation; cell development; cell fate commitment; cellular protein metabolic process; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; response to drug; smooth muscle cell differentiation; transcription from RNA polymerase II promoter
Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot
Reference #:  Q92908 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6
Gene Symbols: GATA6
Molecular weight: 60,033 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA6

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S266‑p
transcription, induced: S266‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 T34‑p FPAREPStPPsPIsS
1 7 S37‑p REPStPPsPIsSSSS
0 1 S40‑p StPPsPIsSSSSSCS
0 1 Y188‑p AAASSPVyVPTTRVG
1 6 S266‑p VSARFPYsPsPPMAN
0 4 S268‑p ARFPYsPsPPMANGA
1 1 Y282‑p AAREPGGyAAAGSGG
0 1 S377‑p LPVPRGPsADLLEDL
1 2 S436‑p KPQKRVPssRRLGLS
0 2 S437‑p PQKRVPssRRLGLSC
0 1 S523‑p PTSTSSNsDDCSKNT
0 1 T530 sDDCSKNTSPTtQPT
0 2 T534‑p SKNTSPTtQPTASGA
  GATA6 iso2  
- gap
- gap
- gap
Y42 AAASSPVYVPTTRVG
S120 VSARFPYSPSPPMAN
S122 ARFPYSPSPPMANGA
Y136 AAREPGGYAAAGSGG
S231 LPVPRGPSADLLEDL
S290‑p KPQKRVPsSRRLGLS
S291 PQKRVPsSRRLGLSC
S377 PTSTSSNSDDCSKNT
T384 SDDCSKNTSPTTQPT
T388 SKNTSPTTQPTASGA
  mouse

 
S34‑p FPAREPSsPLsPISS
S37‑p REPSsPLsPISSSSS
S40 SsPLsPISSSSSSCS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPSPPMAN
S266 ARFPYSPSPPMANGA
Y280 AARDPGGYVAAGGTG
S371 LPVPRGPSTDLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
S517 PTSSSSNSDDCTKNt
T524‑p SDDCTKNtSPSTQAT
T528 TKNtSPSTQATTSGV
  rat

 
S34 FPAREPSSPLSPISS
S37 REPSSPLSPISSSSS
S40 SSPLSPISSSSSSCS
Y188 AAASSPVYVPTTRVG
S264 ASARFPYSPsPPMAN
S266‑p ARFPYSPsPPMANGA
Y280 AARDPGGYVAAGGAG
S371 LPVPRGPSADLLEDL
S430 KPQKRVPSSRRLGLS
S431 PQKRVPSSRRLGLSC
S515 PTSSSSNSDDCTKNT
T522 SDDCTKNTSPPTQST
T526 TKNTSPPTQSTASGV
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