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Protein Page:
GATA6 (human)

GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding
Biological Process: blood coagulation; cell development; cell fate commitment; cellular protein metabolic process; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; response to drug; smooth muscle cell differentiation; transcription from RNA polymerase II promoter
Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot
Reference #:  Q92908 (UniProtKB)
Alt. Names/Synonyms: GATA binding protein 6; GATA-binding factor 6; GATA-binding protein 6; GATA6; Transcription factor GATA-6
Gene Symbols: GATA6
Molecular weight: 60,033 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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