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Protein Page:
TAZ (human)

Overview
TAZ Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4. Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Oncoprotein
Chromosomal Location of Human Ortholog: 3q23-q24
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; transcription coactivator activity
Biological Process: negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase activity; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell division; transcription initiation from RNA polymerase II promoter
Reference #:  Q9GZV5 (UniProtKB)
Alt. Names/Synonyms: DKFZp586I1419; FLJ27004; FLJ45718; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1
Gene Symbols: WWTR1
Molecular weight: 44,101 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAZ

Protein Structure Not Found.


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Sites Implicated In
carcinogenesis, inhibited: S89‑p, S90‑p, S105‑p, T326‑p, T346‑p
cell growth, inhibited: S89‑p, S90‑p, S105‑p, T326‑p, T346‑p
cell motility, inhibited: S89‑p, S90‑p, S105‑p, T326‑p, T346‑p
transcription, altered: S89‑p
transcription, inhibited: S89‑p, S90‑p, S105‑p, T326‑p, T346‑p
activity, inhibited: S89‑p, S90‑p, S105‑p, T326‑p, T346‑p
intracellular localization: S89‑p
protein degradation: S90‑p, S105‑p, T175‑p, T285‑p, S311‑p, T326‑p, T346‑p
ubiquitination: S311‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 22 S58‑p SFFKEPDsGsHsRQs
0 20 S60‑p FKEPDsGsHsRQsst
0 30 S62‑p EPDsGsHsRQsstDs
0 48 S65‑p sGsHsRQsstDssGG
1 62 S66‑p GsHsRQsstDssGGH
0 28 T67‑p sHsRQsstDssGGHP
0 35 S69‑p sRQsstDssGGHPGP
0 27 S70‑p RQsstDssGGHPGPR
0 7 S87‑p GGAQHVRsHssPAsL
12 91 S89‑p AQHVRsHssPAsLQL
2 20 S90‑p QHVRsHssPAsLQLG
0 15 S93‑p RsHssPAsLQLGtGA
0 1 T98‑p PAsLQLGtGAGAAGs
2 18 S105‑p tGAGAAGsPAQQHAH
1 4 S117‑p HAHLRQQsYDVTDEL
1 0 T175‑p LHPAVSStPVPQRSM
1 0 T285‑p AVNPPTMtPDMRsIT
0 1 S290‑p TMtPDMRsITNNsSD
0 2 S295‑p MRsITNNsSDPFLNG
0 1 S296 RsITNNsSDPFLNGG
0 2 S307‑p LNGGPYHsREQstDs
2 9 S311‑p PYHsREQstDsGLGL
0 6 T312‑p YHsREQstDsGLGLG
1 6 S314‑p sREQstDsGLGLGCY
1 0 Y321 sGLGLGCYSVPTtPE
2 0 T326‑p GCYSVPTtPEDFLSN
2 0 T346‑p TGENAGQtPMNINPQ
0 3 S393‑p VESALNKsEPFLTWL
  mouse

 
S58 SFFKEPDSGsHsRQs
S60‑p FKEPDSGsHsRQssT
S62‑p EPDSGsHsRQssTDs
S65‑p SGsHsRQssTDssGG
S66‑p GsHsRQssTDssGGH
T67 sHsRQssTDssGGHP
S69‑p sRQssTDssGGHPGP
S70‑p RQssTDssGGHPGPR
S87 GGAQHVRSHssPAsL
S89‑p AQHVRSHssPAsLQL
S90‑p QHVRSHssPAsLQLG
S93‑p RSHssPAsLQLGTGA
T98 PAsLQLGTGAGAAGG
G105 TGAGAAGGPAQQHAH
S117‑p HAHLRQQsYDVTDEL
T175 LHPSITSTSVPQRSM
S280 PVNTPAMSTDMRSVT
S285 AMSTDMRSVTNSSsD
S290 MRSVTNSSsDPFLNG
S291‑p RSVTNSSsDPFLNGG
S302‑p LNGGPYHsREQSTDs
S306 PYHsREQSTDsGLGL
T307 YHsREQSTDsGLGLG
S309‑p sREQSTDsGLGLGCy
Y316‑p sGLGLGCySVPTTPE
T321 GCySVPTTPEDFLSN
T341 TGENSGQTPMTVNPQ
S388 VESALNKSEPFLTWL
  rat

 
S58 SFFKEPDSGSHSRQS
S60 FKEPDSGSHSRQSST
S62 EPDSGSHSRQSSTDS
S65 SGSHSRQSSTDSSGG
S66 GSHSRQSSTDSSGGH
T67 SHSRQSSTDSSGGHP
S69 SRQSSTDSSGGHPGP
S70 RQSSTDSSGGHPGPR
S87 GGAQHVRSHSSPASL
S89 AQHVRSHSSPASLQL
S90 QHVRSHSSPASLQLG
S93 RSHSSPASLQLGTGA
T98 PASLQLGTGAGAAGG
G105 TGAGAAGGPAQQHAH
S117 HAHLRQQSYDVTDEL
T175 LHPTITSTSVPQRSM
N280 PVNTPAMNTDMRSVT
S285 AMNTDMRSVTNSSSD
S290 MRSVTNSSSDPFLNG
S291 RSVTNSSSDPFLNGG
S302 LNGGPYHSREQSTDS
S306 PYHSREQSTDSGLGL
T307 YHSREQSTDSGLGLG
S309 SREQSTDSGLGLGCY
Y316 SGLGLGCYSVPTTPE
T321 GCYSVPTTPEDFLSN
T341 TGENSGQTPMTVNPQ
S388‑p VESALNKsEPFLTWL
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