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Protein Page:
CDH1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDH1 a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: actin cytoskeleton; apical junction complex; catenin complex; cell junction; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; extracellular region; flotillin complex; focal adhesion; integral to membrane; internal side of plasma membrane; lamellipodium; lateral plasma membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network
Molecular Function: ankyrin binding; beta-catenin binding; cell adhesion molecule binding; gamma-catenin binding; glycoprotein binding; GTPase activating protein binding; protein binding
Biological Process: cell-cell adhesion; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of cell-cell adhesion; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent
Disease: Breast Cancer; Endometrial Cancer; Gastric Cancer, Hereditary Diffuse; Ovarian Cancer; Prostate Cancer
Reference #:  P12830 (UniProtKB)
Alt. Names/Synonyms: Arc-1; CADH1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); Cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell-CAM 120/80; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; LCAM; UVO; Uvomorulin
Gene Symbols: CDH1
Molecular weight: 97,456 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDH1

Protein Structure Not Found.
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Sites Implicated In
cell adhesion, altered: S844‑p
activity, inhibited: T790‑p
intracellular localization: S844‑p
molecular association, regulation: T790‑p, S844‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T66‑p DCTGRQRtAyFsLDT
0 1 Y68‑p TGRQRtAyFsLDTRF
0 1 S70‑p RQRtAyFsLDTRFKV
0 1 T211‑p VFIIEREtGWLKVtE
0 1 T217‑ga EtGWLKVtEPLDRER
0 1 T330‑p TGVISVVtTGLDRES
0 1 T576‑p DNGSPVAtGTGTLLL
0 1 Y663‑p MALEVGDyKINLKLM
0 4 K738‑ub LRRRAVVkEPLLPPE
0 4 T748‑p LLPPEDDtRDNVyyy
1 39 Y753‑p DDtRDNVyyyDEEGG
2 45 Y754‑p DtRDNVyyyDEEGGG
0 43 Y755‑p tRDNVyyyDEEGGGE
0 12 S770‑p EDQDFDLsQLHRGLD
1 0 T790‑p TRNDVAPtLMsVPRy
0 4 S793‑p DVAPtLMsVPRyLPR
0 33 Y797‑p tLMsVPRyLPRPANP
4 0 S838‑p LVFDYEGsGsEAAsL
3 0 S840‑p FDYEGsGsEAAsLSs
3 0 S844‑p GsGsEAAsLSsLNsS
1 0 S846 GsEAAsLSsLNsSEs
3 0 S847‑p sEAAsLSsLNsSEsD
2 0 S850‑p AsLSsLNsSEsDKDQ
1 0 S851 sLSsLNsSEsDKDQD
3 0 S853‑p SsLNsSEsDKDQDYD
0 3 K871‑ub EWGNRFKkLADMyGG
0 28 Y876‑p FKkLADMyGGGEDD_
  mouse

 
T68 GCTGRPRTAFFSEDS
F70 TGRPRTAFFSEDSRF
S72 RPRTAFFSEDSRFKV
T213 VFIIERETGWLKVTQ
T219 ETGWLKVTQPLDREA
T332 TGVISVLTSGLDRES
T578 DDGSPIATGTGTLLL
Y665 KDLEIGEYKIHLKLA
K740‑ub LRRRTVVkEPLLPPD
T750‑p LLPPDDDtRDNVyyY
Y755‑p DDtRDNVyyYDEEGG
Y756‑p DtRDNVyyYDEEGGG
Y757 tRDNVyyYDEEGGGE
S772‑p EDQDFDLsQLHRGLD
T792 TRNDVAPTLMSVPQY
S795 DVAPTLMSVPQYRPR
Y799 TLMSVPQYRPRPANP
S840‑p LVFDYEGsGsEAAsL
S842‑p FDYEGsGsEAAsLss
S846‑p GsGsEAAsLssLNSs
S848‑p GsEAAsLssLNSsEs
S849‑p sEAAsLssLNSsEsD
S852 AsLssLNSsEsDQDQ
S853‑p sLssLNSsEsDQDQD
S855‑p ssLNSsEsDQDQDYD
K873 EWGNRFKKLADMYGG
Y878 FKKLADMYGGGEDD_
  rat

 
T70 GCTGRPRTAFFSEDS
F72 TGRPRTAFFSEDSRF
S74 RPRTAFFSEDSRFKV
T215 VFIIERETGWLKVTQ
T221 ETGWLKVTQPLDREA
T334 TGVISVVTSGLDRES
T580 DDGSPIATGTGTLLL
Y667 KDLEIGEYKINLKLS
K742 LRRRTVVKEPLLPPD
T752 LLPPDDDTRDNVYYY
Y757 DDTRDNVYYYDEEGG
Y758 DTRDNVYYYDEEGGG
Y759 TRDNVYYYDEEGGGE
S774 EDQDFDLSQLHRGLD
T794 IRNDVAPTLMSMPQY
S797 DVAPTLMSMPQYRPR
Y801 TLMSMPQYRPRPANP
S842 LVFDYEGSGSEAASL
S844 FDYEGSGSEAASLSS
S848 GSGSEAASLSSLNSS
S850 GSEAASLSSLNSSES
S851 SEAASLSSLNSSESD
S854 ASLSSLNSSESDQDQ
S855 SLSSLNSSESDQDQD
S857 SSLNSSESDQDQDYD
K875 EWGNRFKKLADMYGG
Y880 FKKLADMYGGGEED_
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