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Protein Page:
TAB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAB2 Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: cytosol; endosome membrane; plasma membrane
Molecular Function: protein binding
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; heart development; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase activity; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway
Disease: Congenital Heart Defects, Multiple Types, 2
Reference #:  Q9NYJ8 (UniProtKB)
Alt. Names/Synonyms: FLJ21885; KIAA0733; MAP3K7IP2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAB2; TAK1-binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Gene Symbols: TAB2
Molecular weight: 76,494 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TAB2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
intracellular localization: S419‑p, S423‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 T171‑p TSSLSQQtPrFNPIM
0 1 R173‑m1 SLSQQtPrFNPIMVT
0 1 R173‑m2 SLSQQtPrFNPIMVT
1 0 K329‑sm RKNQIEIkLEPPQRN
0 3 S350‑p SSGPRTSsTSSSVNS
1 6 S372‑p PTVYIAAsPPNTDEL
0 1 S413‑p TLFISTNsGASAAsR
1 0 S419‑p NsGASAAsRNMsGQV
1 0 S423‑p SAAsRNMsGQVSMGP
0 1 S440‑p IHHHPPKsRAIGNNs
0 1 S447‑p sRAIGNNsATsPRVV
0 17 S450‑p IGNNsATsPRVVVtQ
0 1 T456‑p TsPRVVVtQPNTKYT
0 1 T456 TsPRVVVTQPNTKYT
0 1 S482‑p AVSPGVVsPtFELTN
0 1 T484‑p SPGVVsPtFELTNLL
1 17 S524‑p ISETRKLsMGsDDAA
0 5 S527‑p TRKLsMGsDDAAyTQ
0 1 Y532‑p MGsDDAAyTQALLVH
0 1 S563 KKLDKLKSEVNEMEN
0 1 T573 NEMENNLTRRRLKRs
0 1 S580‑p TRRRLKRsNsISQIP
1 6 S582‑p RRLKRsNsISQIPsL
0 1 S588‑p NsISQIPsLEEMQQL
0 9 K611‑ub IDIDCLTkEIDLFQA
0 3 Y632‑p PSAIHNFyDNIGFVG
0 1 K653‑ub KDQRSIIktPKTQDT
0 2 T654‑p DQRSIIktPKTQDTE
8155 : Phospho-TAB2 (Ser372) (D5A4) Rabbit mAb
  TAB2 iso2  
T171 TSSLSQQTPRFNPIM
R173 SLSQQTPRFNPIMVT
R173 SLSQQTPRFNPIMVT
K329 RKNQIEIKLEPPQRN
S350 SSGPRTSSTSSSVNS
S372 PTVYIAASPPNTDEL
S413 TLFISTNSGASAASR
S419 NSGASAASRNMSGQV
S423 SAASRNMSGQVSMGP
S440 IHHHPPKSRAIGNNS
S447 SRAIGNNSATSPRVV
S450 IGNNSATSPRVVVTQ
T456 TSPRVVVTQPNTKYT
T456 TSPRVVVTQPNTKYT
S482 AVSPGVVSPTFELTN
T484 SPGVVSPTFELTNLL
S524 ISETRKLSMGSDDAA
S527 TRKLSMGSDDAAYTQ
Y532 MGSDDAAYTQDI___
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
T171 TSNLSQQTPrFNPIM
R173 NLSQQTPRFNPIMVT
R173‑m2 NLSQQTPrFNPIMVT
K329 RKNQIEIKLEPPQRN
S350 SSGPRTASTSSLVNS
S372‑p PTVYIAAsPPNTDEM
S413 TLFISTNSGPSAASR
S419 NSGPSAASRNMSGQV
S423 SAASRNMSGQVSMGP
S440 IHHHPPKSRVLGGNS
S447 SRVLGGNSATsPRVV
S450‑p LGGNSATsPRVVVtQ
T456 TsPRVVVTQPNTKYT
T456‑gl TsPRVVVtQPNTKYT
S482 AVSPGVVSPTFELTN
T484 SPGVVSPTFELTNLL
S524‑p ISEARKLsMGsDDAA
S527‑p ARKLsMGsDDAAYTQ
Y532 MGsDDAAYTQALLVH
S563‑p KKLDKLKsEVNEMEN
T573‑p NEMENNLtRRRLKRS
S580 tRRRLKRSNsISQIP
S582‑p RRLKRSNsISQIPSL
S588 NsISQIPSLEEMQQL
K611‑ub IDIDCLTkEIDLFQA
Y632 PSAIHNFYDNIGFVG
K653 KDQRSTIKAPKTQDA
A654 DQRSTIKAPKTQDAE
8155 : Phospho-TAB2 (Ser372) (D5A4) Rabbit mAb
  rat

 
T171 TSNLSQQTPRFNPIM
R173 NLSQQTPRFNPIMVT
R173 NLSQQTPRFNPIMVT
K329 RKNQIEIKLEPPQRN
S350 SSGPRTASTSSLVNS
S372‑p PTVYIAAsPPSTDEM
S413 TLFISTNSGASAASR
S419 NSGASAASRNMSGQV
S423 SAASRNMSGQVSMGP
S440 IHHHPPKSRVLGGNS
S447 SRVLGGNSAASPRVV
S450 LGGNSAASPRVVVTQ
T456 ASPRVVVTQPNTKYT
T456 ASPRVVVTQPNTKYT
S482 AVSPGVVSPTFELTN
T484 SPGVVSPTFELTNLL
S524 VSEARKLSMGSDDAA
S527 ARKLSMGSDDAAYTQ
Y532 MGSDDAAYTQALLVH
S563 KKLDKLKSEVNEMEN
T573 NEMENSLTRRRLKRS
S580 TRRRLKRSNSMSQIP
S582 RRLKRSNSMSQIPSL
S588 NSMSQIPSLEEMQQL
K611 IDIDCLTKEIDLFQA
Y632 PSAIHNFYDNIGFVG
K653 KDQRSTIKAPKTQDT
A654 DQRSTIKAPKTQDTE
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