a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. Causes the formation of thin, actin-rich surface projections called filopodia. The oncoprotein Dbl specifically catalyzes the dissociation of GDP from this protein. Regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Interacts with DOCK9 which activates it by exchanging GDP for GTP. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with PARD3, PARD6A or PARD6B and PRKCI or PRKCZ. Interacts with CDC42EP4.Alternative splicing of this gene results in at least two transcript variants. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, Rho; G protein; Motility/polarity/chemotaxis; G protein, monomeric
Molecular Function: GTP binding; GTP-dependent protein binding; GTPase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase binding; Rho GDP-dissociation inhibitor binding
Biological Process: actin filament bundle formation; actin filament organization; cell differentiation; cell-cell adhesion; endocytosis; endosome transport; epidermis morphogenesis; establishment and/or maintenance of apical/basal cell polarity; establishment and/or maintenance of cell polarity; establishment of Golgi localization; filopodium formation; Golgi organization and biogenesis; hair follicle morphogenesis; heart contraction; keratinization; multicellular organism growth; nervous system development; neuron fate determination; nuclear migration; nucleus localization; positive regulation of DNA replication; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of metalloenzyme activity; positive regulation of neuron apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of synapse structural plasticity; regulation of mitosis; regulation of protein catabolic process; regulation of protein heterodimerization activity; regulation of protein kinase activity; regulation of protein metabolic process; regulation of protein stability; Rho protein signal transduction; small GTPase mediated signal transduction; sprouting angiogenesis; Wnt receptor signaling pathway through beta-catenin
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.