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Protein Page:
CDC16 (human)

Overview
CDC16 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. Belongs to the APC6/CDC16 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: anaphase-promoting complex; centrosome; cytoplasm; cytosol; nucleoplasm; spindle; spindle microtubule
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of mitosis; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Reference #:  Q13042 (UniProtKB)
Alt. Names/Synonyms: ANAPC6; Anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6; APC6; CDC16; CDC16 homolog; CDC16Hs; cell division cycle 16 homolog (S. cerevisiae); Cell division cycle protein 16 homolog; Cyclosome subunit 6
Gene Symbols: CDC16
Molecular weight: 71,656 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC16

Protein Structure Not Found.
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