This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. Homodimer; disulfide-linked. Interacts with APEX1. Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta. Belongs to the peptidase S1 family. Granzyme subfamily. 2 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Protease; Secreted; Apoptosis; EC 188.8.131.52
Molecular Function: protein binding; protein homodimerization activity; serine-type endopeptidase activity
Biological Process: apoptosis; cytolysis; immune response; negative regulation of DNA binding; negative regulation of endodeoxyribonuclease activity; negative regulation of oxidoreductase activity; positive regulation of apoptosis; proteolysis involved in cellular protein catabolic process
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.