Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
MBTPS2 (human)

MBTPS2 Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.12-p22.11
Cellular Component: cytoplasm; Golgi membrane; integral to membrane
Molecular Function: metal ion binding; metalloendopeptidase activity; metallopeptidase activity
Biological Process: cholesterol metabolic process; membrane protein intracellular domain proteolysis; positive regulation of transcription factor activity
Disease: Ifap Syndrome With Or Without Bresheck Syndrome; Keratosis Follicularis Spinulosa Decalvans, X-linked; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked
Reference #:  O43462 (UniProtKB)
Gene Symbols: MBTPS2
Molecular weight: 57,444 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 S115 DSPSSYSSssSssSS
0 1 S116‑p SPSSYSSssSssSSS
0 2 S117‑p PSSYSSssSssSSSS
0 2 S119‑p SYSSssSssSSSSss
0 1 S120‑p YSSssSssSSSSssS
0 2 S125‑p SssSSSSssSSSSSS
0 2 S126‑p ssSSSSssSSSSSSS

S115‑p DSPSPYSsSsSsSss
S117‑p PSPYSsSsSsSssSS
S119‑p PYSsSsSsSssSSSS
S121‑p SsSsSsSssSSSSSS
S122‑p sSsSsSssSSSSSSS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.