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Protein Page:
MBTPS2 (human)

Overview
MBTPS2 Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the peptidase M50A family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.85; Protease; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.12-p22.11
Cellular Component: cytoplasm; Golgi membrane; integral to membrane
Molecular Function: metal ion binding; metalloendopeptidase activity; metallopeptidase activity
Biological Process: cholesterol metabolic process; membrane protein intracellular domain proteolysis; positive regulation of transcription factor activity
Disease: Ifap Syndrome With Or Without Bresheck Syndrome; Keratosis Follicularis Spinulosa Decalvans, X-linked; Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-linked
Reference #:  O43462 (UniProtKB)
Gene Symbols: MBTPS2
Molecular weight: 57,444 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MBTPS2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S115 DSPSSYSSssSssSS
0 1 S116‑p SPSSYSSssSssSSS
0 2 S117‑p PSSYSSssSssSSSS
0 2 S119‑p SYSSssSssSSSSss
0 1 S120‑p YSSssSssSSSSssS
0 2 S125‑p SssSSSSssSSSSSS
0 2 S126‑p ssSSSSssSSSSSSS
0 1 S265‑p ITEVAEDsPAIGPRG
  mouse

 
S115‑p DSPSPYSsSsSsSss
S116 SPSPYSsSsSsSssS
S117‑p PSPYSsSsSsSssSS
S119‑p PYSsSsSsSssSSSS
S120 YSsSsSsSssSSSSS
S121‑p SsSsSsSssSSSSSS
S122‑p sSsSsSssSSSSSSS
S261 ITEVAEDSPAIGPRG
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