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Protein Page:
SGK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SGK2 Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Highly expressed in liver, kidney and pancreas, and at lower levels in brain. Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser- 416), need to be phsphorylated for its full activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; SGK family
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: cytosol; intracellular; nucleus
Molecular Function: ATP binding; calcium channel regulator activity; chloride channel regulator activity; potassium channel regulator activity; protein serine/threonine kinase activity; sodium channel regulator activity
Biological Process: cellular sodium ion homeostasis; peptidyl-serine phosphorylation; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell growth; regulation of cell proliferation; response to oxidative stress
Reference #:  Q9HBY8 (UniProtKB)
Alt. Names/Synonyms: dJ138B7.2; H-SGK2; Serine/threonine-protein kinase Sgk2; serum/glucocorticoid regulated kinase 2; Serum/glucocorticoid-regulated kinase 2; SGK2
Gene Symbols: SGK2
Molecular weight: 47,604 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SGK2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S70 SSPAGTPSPQPSRAN
0 1 T251‑p GVEPEDTtStFCGTP
1 2 T253‑p EPEDTtStFCGTPEY
0 1 Y285‑p WCLGAVLyEMLHGLP
0 1 K331 LLQSLLHKDQRQRLG
0 1 K363 NWDDLYHKRLtPPFN
0 2 T366‑p DLYHKRLtPPFNPNV
0 1 T374‑p PPFNPNVtGPADLKH
  SGK2 iso2  
S10 SSPAGTPSPQPSRAN
T191 GVEPEDTTSTFCGTP
T193 EPEDTTSTFCGTPEY
Y225 WCLGAVLYEMLHGLP
K271 LLQSLLHKDQRQRLG
K303 NWDDLYHKRLTPPFN
T306 DLYHKRLTPPFNPNV
T314 PPFNPNVTGPADLKH
  SGK2 iso3  
S36 SSPAGTPSPQPSRAN
T217 GVEPEDTTSTFCGTP
T219 EPEDTTSTFCGTPEY
Y251 WCLGAVLYEMLHGLP
K297 LLQSLLHKDQRQRLG
K329 NWDDLYHKRLTPPFN
T332 DLYHKRLTPPFNPNV
T340 PPFNPNVTGPADLKH
  mouse

 
S10 SSPVGVPSPQPSRAN
T191 CVEPEETTStFCGTP
T193‑p EPEETTStFCGTPEY
Y225 WCLGAVLYEMLHGLP
K271‑ub LLQGLLHkDQRQRLG
K303‑ub NWDDLYHkRLtPPFN
T306‑p DLYHkRLtPPFNPNV
E314 PPFNPNVEGPADLKH
  rat

 
S10‑p SSPVGVPsPQPSRAN
T191 CVEPEETTSTFCGTP
T193 EPEETTSTFCGTPEY
Y225 WCLGAVLYEMLHGLP
K271 LLQGLLHKDQRQRLG
K303 NWDDLYHKRLTPPFN
T306 DLYHKRLTPPFNPNV
E314 PPFNPNVEGPADLKH
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