Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
GPX1 (human)

GPX1 Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion
Molecular Function: glutathione peroxidase activity; SH3 domain binding
Biological Process: cell redox homeostasis; glutathione metabolic process; heart contraction; hydrogen peroxide catabolic process; lipoxygenase pathway; negative regulation of caspase activity; purine nucleotide catabolic process; regulation of gene expression, epigenetic; regulation of mammary gland epithelial cell proliferation; response to hydrogen peroxide; response to reactive oxygen species; response to selenium ion; UV protection
Disease: Glutathione Peroxidase Deficiency
Reference #:  P07203 (UniProtKB)
Alt. Names/Synonyms: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; GPX1; GSHPx-1; GSHPX1; MGC14399; MGC88245
Gene Symbols: GPX1
Molecular weight: 22,088 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein