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Protein Page:
CDH5 (human)

CDH5 Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Endothelial tissues and brain. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cell junction; cell surface; intercellular junction; membrane; plasma membrane
Molecular Function: beta-catenin binding; protein binding; receptor binding
Biological Process: intercellular junction assembly; transforming growth factor beta receptor signaling pathway
Reference #:  P33151 (UniProtKB)
Alt. Names/Synonyms: 7B4; 7B4 antigen; CADH5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VE-cadherin
Gene Symbols: CDH5
Molecular weight: 87,528 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
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