Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; RIPK family
Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein complex binding; protein kinase activity; protein serine/threonine kinase activity; transcription coactivator activity
Biological Process: activation of NF-kappaB transcription factor; activation of protein kinase activity; I-kappaB kinase/NF-kappaB cascade; innate immune response; lymph node development; MyD88-independent toll-like receptor signaling pathway; positive regulation of interferon type I production; positive regulation of ligase activity; positive regulation of oxidoreductase activity; programmed cell death; protein amino acid autophosphorylation; protein heterooligomerization; protein homooligomerization; protein modification process; regulation of activated T cell proliferation; regulation of adaptive immune response; regulation of interferon-gamma production; regulation of T cell mediated cytotoxicity; signal transduction; spleen development; T cell differentiation in the thymus; T cell homeostasis; thymus development; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.