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Protein Page:
HDAC3 (human)

Overview
HDAC3 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15. Widely expressed. Belongs to the histone deacetylase family. HD type 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; nucleoplasm; nucleus; plasma membrane; spindle microtubule; transcriptional repressor complex
Molecular Function: chromatin binding; cyclin binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; NF-kappaB binding; protein binding; protein deacetylase activity; transcription corepressor activity; transcription factor binding
Biological Process: cellular lipid metabolic process; chromatin modification; circadian rhythm; negative regulation of apoptosis; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; positive regulation of TOR signaling pathway; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein amino acid deacetylation; regulation of protein stability; spindle assembly
Reference #:  O15379 (UniProtKB)
Alt. Names/Synonyms: HD3; HDAC3; Histone deacetylase 3; RPD3; RPD3-2; SMAP45
Gene Symbols: HDAC3
Molecular weight: 48,848 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HDAC3

Protein Structure Not Found.
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