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Protein Page:
VAV3 (human)

Overview
VAV3 a guanine nucleotide exchange factor (GEF) that activates RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by activated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion. Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation. Down-regulated by EGF and TGF-beta. Four isoforms of the human protein are produced by alternative promoter. Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: cytosol
Molecular Function: GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity
Biological Process: B cell receptor signaling pathway; ephrin receptor signaling pathway; platelet activation; positive regulation of apoptosis; positive regulation of B cell proliferation; regulation of cell size; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; response to DNA damage stimulus; response to drug; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q9UKW4 (UniProtKB)
Alt. Names/Synonyms: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3; VAV3
Gene Symbols: VAV3
Molecular weight: 97,776 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VAV3

Protein Structure Not Found.
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