a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Wnk family
Molecular Function: ATP binding; chloride channel inhibitor activity; phosphatase binding; protein binding; protein kinase activator activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: ion transport; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; protein amino acid phosphorylation; regulation of cellular process; regulation of sodium ion transport