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Protein Page:
WNK1 (human)

WNK1 a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Wnk family
Chromosomal Location of Human Ortholog: 12p13.3
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: ATP binding; chloride channel inhibitor activity; phosphatase binding; protein kinase activator activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process: ion transport; peptidyl-threonine phosphorylation; positive regulation of ion transmembrane transporter activity; protein amino acid phosphorylation; regulation of cellular process; regulation of sodium ion transport
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic
Reference #:  Q9H4A3 (UniProtKB)
Alt. Names/Synonyms: Erythrocyte 65 kDa protein; HSAN2; HSN2; hWNK1; KDP; KIAA0344; p65; PHA2C; PRKWNK1; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein kinase, lysine deficient 1; PSK; Serine/threonine-protein kinase WNK1; WNK lysine deficient protein kinase 1; WNK1
Gene Symbols: WNK1
Molecular weight: 250,794 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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