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Protein Page:
GATA2 (human)

Overview
GATA2 Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; transcription factor activity; transcription factor binding
Biological Process: blood coagulation; gut development; heart development; negative regulation of fat cell differentiation; negative regulation of Notch signaling pathway; organ morphogenesis; positive regulation of angiogenesis; positive regulation of phagocytosis; positive regulation of transcription from RNA polymerase II promoter; tissue development; transcription, DNA-dependent
Disease: Immunodeficiency 21; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome
Reference #:  P23769 (UniProtKB)
Alt. Names/Synonyms: Endothelial transcription factor GATA-2; FLJ45948; GATA binding protein 2; GATA-binding protein 2; GATA2; MGC2306; NFE1B
Gene Symbols: GATA2
Molecular weight: 50,500 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GATA2

Protein Structure Not Found.


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