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Protein Page:
TGFBR3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: cell surface; external side of plasma membrane; extracellular space; integral to plasma membrane; receptor complex
Molecular Function: coreceptor activity; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; punt binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cell growth; cell migration; epithelial to mesenchymal transition; heart morphogenesis; immune response; liver development; negative regulation of cell motility; negative regulation of epithelial cell proliferation; palate development; response to follicle-stimulating hormone stimulus; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle morphogenesis
Reference #:  Q03167 (UniProtKB)
Alt. Names/Synonyms: Betaglycan; betaglycan proteoglycan; BGCAN; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III
Gene Symbols: TGFBR3
Molecular weight: 93,499 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TGFBR3

Protein Structure Not Found.
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Sites Implicated In
intracellular localization: T843‑p
molecular association, regulation: T843‑p
receptor internalization, altered: T843‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T84‑p GQLQREVtLHLNPIS
0 1 T369‑ga MGDEEVHtIPPELRI
0 1 K722 KHPQKLPKCVPPDEA
1 0 S831‑p SPPASENsSAAHSIG
1 0 T843‑p SIGSTQStPCSSSST
  mouse

 
T86 GQPQREVTLHLNPIA
T370 MRDEEVHTIPPELRI
K720‑ub KGSQKLPkCVTPDDA
S830 SPPASENSSAAHSIG
T842 SIGSTQSTPCSSSST
  rat

 
T87 GQRQREVTLHLNPIA
T371 MRDEEVHTIPPELRI
R722 KGSLKLPRCVTPDDA
S833 SPPASENSSAAHSIG
T845 SIGSTQSTPCSSSST
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