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Protein Page:
PKG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKG1 an AGC kinase of the PKG family. Type I cGMP-dependent protein kinase; relaxes vascular smooth muscle and inhibits platelet aggregation. Binding of cGMP results in enzyme activation. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.12; Protein kinase, AGC; AGC group; PKG family
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; plasma membrane
Molecular Function: ATP binding; calcium channel regulator activity; cGMP binding; cGMP-dependent protein kinase activity; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; blood coagulation; cGMP-mediated signaling; dendrite development; forebrain development; neuron migration; protein amino acid phosphorylation; regulation of GTPase activity; relaxation of vascular smooth muscle; signal transduction
Reference #:  Q13976 (UniProtKB)
Alt. Names/Synonyms: cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; DKFZp686K042; FLJ36117; KGP1; MGC71944; PGK; PKG; PRKG1; PRKG1B; PRKGR1A; PRKGR1B; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I
Gene Symbols: PRKG1
Molecular weight: 76,364 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKG1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
transcription, altered: T517‑p
enzymatic activity, induced: T59‑p, S65‑p, T517‑p
phosphorylation: T517‑p
ubiquitination: S65‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S27 KELEKRLSEKEEEIQ
2 0 S45 RKLHKCQSVLPVPsT
4 0 S51‑p QSVLPVPsTHIGPRT
5 0 T59‑p THIGPRTtRAQGIsA
4 0 S65‑p TtRAQGIsAEPQTYR
1 0 T70 GIsAEPQTYRSFHDL
3 0 S73 AEPQTYRSFHDLRQA
3 0 T85‑p RQAFRKFtKSERSKD
0 1 - gap
1 0 - gap
3 2 - gap
0 1 - gap
0 1 - gap
3 0 - gap
1 0 S90 KFtKSERSKDLIKEA
0 1 Y212‑p GLIKHTEyMEFLKsV
0 1 S218‑p EyMEFLKsVPTFQSL
0 1 S224 KsVPTFQSLPEEILs
0 1 S231‑p SLPEEILsKLADVLE
0 1 Y247‑p THYENGEyIIRQGAR
0 3 S273‑p VNVTREDsPSEDPVF
0 1 K322 VIDRDSFKHLIGGLD
0 1 Y433‑p RTFKDSKyLyMLMEA
0 1 Y435‑p FKDSKyLyMLMEACL
0 2 R483 HSKGIIYRDLKPENL
0 1 Y497‑p LILDHRGyAKLVDFG
0 1 K513 AKKIGFGKKtWtFCG
0 5 T515‑p KIGFGKKtWtFCGTP
1 14 T517‑p GFGKKtWtFCGTPEY
0 1 T521 KtWtFCGTPEYVAPE
0 1 K582 DMIEFPKKIAKNAAN
0 3 K607‑ac SERLGNLkNGVKDIQ
0 3 K615‑ac NGVKDIQkHkWFEGF
0 3 K617‑ac VKDIQkHkWFEGFNW
0 1 S647 VASPTDTSNFDSFPE
  PKG1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y10‑p GTLRDLQyALQEKIE
T58 RSVIRPATQQAQKQs
S65‑p TQQAQKQsASTLQGE
S67 QAQKQsASTLQGEPR
T75‑p TLQGEPRtKRQAIsA
S81‑p RtKRQAIsAEPTAFD
S106 FYPKSPQSKDLIKEA
Y228 GLIKHTEYMEFLKSV
S234 EYMEFLKSVPTFQSL
S240 KSVPTFQSLPEEILS
S247 SLPEEILSKLADVLE
Y263 THYENGEYIIRQGAR
S289 VNVTREDSPSEDPVF
K338 VIDRDSFKHLIGGLD
Y449 RTFKDSKYLYMLMEA
Y451 FKDSKYLYMLMEACL
R499 HSKGIIYRDLKPENL
Y513 LILDHRGYAKLVDFG
K529 AKKIGFGKKTWTFCG
T531 KIGFGKKTWTFCGTP
T533 GFGKKTWTFCGTPEY
T537 KTWTFCGTPEYVAPE
K598 DMIEFPKKIAKNAAN
K623 SERLGNLKNGVKDIQ
K631 NGVKDIQKHKWFEGF
K633 VKDIQKHKWFEGFNW
S663 VASPTDTSNFDSFPE
  mouse

► Hide Isoforms
 
S27 KELEKRLSEKEEEIQ
S45 RKLHKCQSVLPVPsT
S51‑p QSVLPVPsTHIGPRT
T59‑p THIGPRTtRAQGISA
S65 TtRAQGISAEPQTYR
T70 GISAEPQTYRsFHDL
S73‑p AEPQTYRsFHDLRQA
T85‑p RQAFRKFtKSERSKD
- gap
- gap
- gap
- gap
- gap
- gap
S90 KFtKSERSKDLIKEA
Y212 GLIKHTEYMEFLKSV
S218 EYMEFLKSVPTFQsL
S224‑p KSVPTFQsLPDEILS
S231 sLPDEILSKLADVLE
Y247 THYENGEYIIRQGAR
S273‑p VNVTREDsPSEDPVF
K322 VIDRDSFKHLIGGLD
Y433 RTFKDSKYLYMLMEA
Y435 FKDSKYLYMLMEACL
R483‑m1 HSKGIIYrDLKPENL
Y497 LILDHRGYAKLVDFG
K513‑ac AKKIGFGkKtWtFCG
T515‑p KIGFGkKtWtFCGtP
T517‑p GFGkKtWtFCGtPEY
T521‑p KtWtFCGtPEYVAPE
K582‑ac DMIEFPKkIAKNAAN
K607 SERLGNLKNGVKDIQ
K615 NGVKDIQKHKWFEGF
K617 VKDIQKHKWFEGFNW
S647‑p VASPTDTsNFDSFPE
  PKG1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y10 GTLRDLQYALQEKIE
T58‑p RSVIRPAtQQAQKQs
S65‑p tQQAQKQsAsTLQGE
S67‑p QAQKQsAsTLQGEPR
T75 TLQGEPRTKRQAIsA
S81‑p RTKRQAIsAEPTAFD
S106 FYPKSPQSKDLIKEA
Y228 GLIKHTEYMEFLKSV
S234 EYMEFLKSVPTFQSL
S240 KSVPTFQSLPDEILS
S247 SLPDEILSKLADVLE
Y263 THYENGEYIIRQGAR
S289 VNVTREDSPSEDPVF
K338 VIDRDSFKHLIGGLD
Y449 RTFKDSKYLYMLMEA
Y451 FKDSKYLYMLMEACL
R499 HSKGIIYRDLKPENL
Y513 LILDHRGYAKLVDFG
K529 AKKIGFGKKTWTFCG
T531 KIGFGKKTWTFCGTP
T533 GFGKKTWTFCGTPEY
T537 KTWTFCGTPEYVAPE
K598 DMIEFPKKIAKNAAN
K623 SERLGNLKNGVKDIQ
K631 NGVKDIQKHKWFEGF
K633 VKDIQKHKWFEGFNW
S663 VASPTDTSNFDSFPE
  rat

 
S27 KELEKRLSEKEEEIQ
S45‑p RKLHKCQsVLPVPsT
S51‑p QsVLPVPsTHIGPRT
T59‑p THIGPRTtRAQGIsA
S65‑p TtRAQGIsAEPQtYR
T70‑p GIsAEPQtYRsFHDL
S73‑p AEPQtYRsFHDLRQA
T85 RQAFRKFTKSERsKD
- gap
- gap
- gap
- gap
- gap
- gap
S90‑p KFTKSERsKDLIKEA
Y212 GLIKHTEYMEFLKSV
S218 EYMEFLKSVPTFQSL
S224 KSVPTFQSLPDEILS
S231 SLPDEILSKLADVLE
Y247 THYENGEYIIRQGAR
S273 VSVTREDSPSEDPVF
K322‑ac VIDRDSFkHLIGGLD
Y433 RTFKDSKYLYMLMEA
Y435 FKDSKYLYMLMEACL
R483 HSKGIIYRDLKPENL
Y497 LILDHRGYAELVDFG
K513 AKKIGFGKKTWtFCG
T515 KIGFGKKTWtFCGTP
T517‑p GFGKKTWtFCGTPEY
T521 KTWtFCGTPEYVAPE
K582 DMIEFPKKIAKSAAN
K607 SERLGNLKNGVKDIQ
K615 NGVKDIQKHKWFEGF
K617 VKDIQKHKWFEGFNW
S647 VASPTDTSNFDSFPE
  cow

 
S27‑p KELEKRLsEKEEEIQ
S45‑p RKLHKCQsVLPVPsT
S51‑p QsVLPVPsTHIGPRT
T59‑p THIGPRTtRAQGIsA
S65‑p TtRAQGIsAEPQTYR
T70 GIsAEPQTYRsFHDL
S73‑p AEPQTYRsFHDLRQA
T85‑p RQAFRKFtKSERSKD
- gap
- gap
- gap
- gap
- gap
- gap
S90 KFtKSERSKDLIKEA
Y212 GLIKHTEYMEFLKSV
S218 EYMEFLKSVPTFQSL
S224 KSVPTFQSLPEEILS
S231 SLPEEILSKLADVLE
Y247 THYENGEYIIRQGAR
S273 VNVTREDSPNEDPVF
K322 VIDRDSFKHLIGGLD
Y433 RTFKDSKYLYMLMEA
Y435 FKDSKYLYMLMEACL
R483 HSKGIIYRDLKPENL
Y497 LILDHRGYAKLVDFG
K513 AKKIGFGKKTWtFCG
T515 KIGFGKKTWtFCGTP
T517‑p GFGKKTWtFCGTPEY
T521 KTWtFCGTPEYVAPE
K582 DMIEFPKKIAKNAAN
K607 SERLGNLKNGVKDIQ
K615 NGVKDIQKHKWFEGF
K617 VKDIQKHKWFEGFNW
S647 VASPTDTSNFDSFPE
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