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Protein Page:
PAX2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAX2 Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. Interacts with ELGN3; the interaction targets PAX2 for destruction. Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: Golgi apparatus; microtubule organizing center; nucleolus; nucleus; protein complex
Molecular Function: DNA binding; protein binding; superoxide-generating NADPH oxidase activity; transcription factor binding
Biological Process: axonogenesis; brain morphogenesis; camera-type eye development; cell fate determination; glial cell differentiation; inner ear morphogenesis; mesodermal cell fate specification; mesonephros development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cytolysis; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; neural tube closure; optic cup morphogenesis involved in camera-type eye development; optic nerve development; optic nerve morphogenesis; optic nerve structural organization; positive regulation of epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; pronephros development; protein kinase B signaling cascade; stem cell differentiation; transcription from RNA polymerase II promoter; transcription, DNA-dependent; ureteric bud branching; urogenital system development; vestibulocochlear nerve formation; visual perception
Disease: Focal Segmental Glomerulosclerosis 7; Papillorenal Syndrome; Renal Hypodysplasia/aplasia 1
Reference #:  Q02962 (UniProtKB)
Alt. Names/Synonyms: paired box 2; paired box homeotic gene 2; Paired box protein Pax-2; PAX2
Gene Symbols: PAX2
Molecular weight: 44,706 Da
Basal Isoelectric point: 7.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAX2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y72 VSKILGRYYETGSIK
0 1 K79 YYETGSIKPGVIGGS
0 2 K98‑ac ATPKVVDkIAEYKRQ
0 1 T226‑p GGLHLVWtLRDVSEG
0 1 T255 RKHLRADTFTQQQLE
  PAX2 iso2  
Y72 VSKILGRYYETGSIK
K79 YYETGSIKPGVIGGS
K98 ATPKVVDKIAEYKRQ
T226 GGLHLVWTLRDVSEG
T255 RKHLRADTFTQQQLE
  mouse

 
Y71‑p VSKILGRyYETGSIK
K78 yYETGSIKPGVIGGS
K97 ATPKVVDKIAEYKRQ
T225 GGLHLVWTLRDVSEG
T254 RKHLRADTFTQQQLE
  rat

 
Y71 VSKILGRYYETGSIk
K78‑ac YYETGSIkPGVIGGS
K97‑ac ATPKVVDkIAEYKRQ
T225 GGLHLVWTLRDVSEG
T254‑p RKHLRADtFTQQQLE
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