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Protein Page:
IL2RA (human)

Overview
IL2RA Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p15-p14
Cellular Component: external side of plasma membrane; integral to membrane; intracellular; plasma membrane
Molecular Function: drug binding; interleukin-2 binding; interleukin-2 receptor activity
Biological Process: activated T cell apoptosis; activation of MAPKK activity; apoptosis; axon guidance; cell proliferation; cell surface receptor linked signal transduction; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of defense response to virus; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of T cell proliferation; nerve growth factor receptor signaling pathway; Notch signaling pathway; positive regulation of activated T cell proliferation; positive regulation of T cell differentiation; Ras protein signal transduction; regulation of T cell homeostatic proliferation; regulation of T cell tolerance induction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of
Reference #:  P01589 (UniProtKB)
Alt. Names/Synonyms: CD25; IDDM10; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; IL2R; IL2RA; interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR
Gene Symbols: IL2RA
Molecular weight: 30,819 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IL2RA

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S268‑p WQRRQRKsRRtI___
1 0 T271‑p RQRKsRRtI______
  mouse

 
S264 WQHRWRKSRRTI___
T267 RWRKSRRTI______
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